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Article
SLAMF7 Promotes Foam Cell Formation of Macrophage by Suppressing NR4A1 Expression During Carotid Atherosclerosis
Macrophage-derived lipid-laden foam cells from the subendothelium play a crucial role in the initiation and progression of atherosclerosis. However, the molecule mechanism that regulates the formation of foam ...
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Article
LNCGM1082-mediated NLRC4 activation drives resistance to bacterial infection
The activation of NLRC4 is a major host response against intracellular bacteria infection. However, NLRC4 activation after a host senses diverse stimuli is difficult to understand. Here, we found that the lncRNA
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Article
Open AccessLncRNA lncLy6C induced by microbiota metabolite butyrate promotes differentiation of Ly6Chigh to Ly6Cint/neg macrophages through lncLy6C/C/EBPβ/Nr4A1 axis
Macrophages are mainly divided into two populations, which play a different role in physiological and pathological conditions. The differentiation of these cells may be regulated by transcription factors. Howe...
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Article
Separating the contributions of climate change and human activities to regional AET variability by using a developed analytical framework
Actual evapotranspiration (AET) is a key factor in land-atmosphere interactions and a major hydrological cycle component. Variations in AET have resulted from a combination of climate change (CC) and human act...
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Article
Open AccessReg4 and complement factor D prevent the overgrowth of E. coli in the mouse gut
The expansion of Enterobacteriaceae, such as E. coli is a main characteristic of gut inflammation and is related to multiple human diseases. However, how to control these E. coli overgrowth is not well understood...
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Article
Open AccessLactobacillus maintains healthy gut mucosa by producing L-Ornithine
Gut mucosal layers are crucial in maintaining the gut barrier function. Gut microbiota regulate homeostasis of gut mucosal layer via gut immune cells such as RORγt (+) IL-22(+) ILC3 cells, which can influence ...
