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Article
Simultaneously Strengthening and Toughening Biodegradable Polylactic Acid/Thermoplastic Starch Blends by Compatibilizing with Epoxy-Terminated Hyperbranched Polyester
Thermoplastic starch (TPS) as a renewable filler and biodegradable polyester polylactic acid (PLA) blending is a cost-effective and feasible method. To improve the performance and compatibility of PLA/TPS blen...
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Article
Open AccessIdentification of osteoarthritis-characteristic genes and immunological micro-environment features through bioinformatics and machine learning-based approaches
Osteoarthritis (OA) is a multifaceted chronic joint disease characterized by complex mechanisms. It has a detrimental impact on the quality of life for individuals in the middle-aged and elderly population whi...
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Article
Open AccessMultivariate modular metabolic engineering for enhanced l-methionine biosynthesis in Escherichia coli
l-Methionine is the only bulk amino acid that has not been industrially produced by the fermentation method. Due to highly complex and strictly regulated biosynthesis, the development of microbial strains for h.....
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Article
Open AccessImproving adenine and dual base editors through introduction of TadA-8e and Rad51DBD
Base editors, including dual base editors, are innovative techniques for efficient base conversions in genomic DNA. However, the low efficiency of A-to-G base conversion at positions proximal to the protospace...
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Article
Toughening Modification of Polylactic Acid by Long-Chain Hyperbranched Polymers Containing Polycaprolactone end Groups
The hyperbranched polyester (HBPEs) were synthesized by the "one-step method" and grafted with caprolactone (ε-Cl) to obtain long-chain hyperbranched polymers (LCHBPs-Cl). In this study, LCHBPs-Cl with Cl long...
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Article
Wnt Signaling in Heart Development and Regeneration
Cardiovascular diseases are the leading cause of death worldwide, largely due to the limited regenerative capacity of the adult human heart. In contrast, teleost zebrafish hearts possess natural regeneration c...
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Article
Open AccessAnalysis of the expression and potential molecular mechanism of interleukin-1 receptor antagonist (IL1RN) in papillary thyroid cancer via bioinformatics methods
Interleukin-1 receptor antagonist (IL1RN) has been reported as a biomarker of many cancers. However, the biological function of IL1RN in papillary thyroid carcinoma (PTC) remains undetermined.
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Article
Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport
Cilia are microtubule-based organelles that mediate signal transduction in a variety of tissues. Despite their importance, the signalling cascades that regulate cilium formation remain incompletely understood...
