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Article

Flexible TAM requirement of TnpB enables efficient single-nucleotide editing with expanded targeting scope

TnpBs encoded by the IS200/IS605 family transposon are among the most abundant prokaryotic proteins from which type V CRISPR-Cas nucleases may have evolved. Since bacterial TnpBs can be programmed for RNA-guid...

Xu Feng, Ruyi Xu, Jianglan Liao, **gyu Zhao, Baochang Zhang… in Nature Communications (2024)