-
Article
Open AccessEstablishment and characterization of a novel multidrug-resistant pancreatic ductal adenocarcinoma cell line, PDAC-X1
Drug resistance remains a significant challenge in the treatment of pancreatic cancer. The development of drug-resistant cell lines is crucial to understanding the underlying mechanisms of resistance and devel...
-
Article
Open AccessECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis
The Enoyl-CoA hydratase/isomerase family plays a crucial role in the metabolism of tumors, being crucial for maintaining the energy balance and biosynthetic needs of cancer cells. However, the enzymes within t...
-
Article
Open AccessA novel multidrug-resistant cell line from a Chinese patient with pancreatic ductal adenocarcinoma
Chemotherapy resistance poses clinical challenges in pancreatic cancer treatment. Develo** cell lines resistant to chemotherapy is crucial for investigating drug resistance mechanisms and identifying alterna...
-
Article
Establishment and characterization of DPC-X4: a novel mixed-type ampullary cancer cell line
Mixed-type ampullary cancer is a distinct subtype of ampullary cancer that manifests a merging of the biological characteristics of both intestinal and pancreaticobiliary subtypes. The absence of established c...
-
Article
Open AccessMultidimensional diversity of bird communities across spatial variation of land cover in Zoige on the eastern Qinghai-Tibetan Plateau
Spatial variation of land cover can result in the changes of community similarities and biotic homogenization, whereby the increasing similarity would reduce the adaptive capacity of biotic assemblages to furt...
-
Article
Open AccessBeneficial effects of paeoniflorin on non-alcoholic fatty liver disease induced by high-fat diet in rats
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver diseases. This study sought to evaluate the insulin-sensitizing effect of paeoniflorin (PF) on high-fat diet-induced NAFLD ...
