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Article
Open AccessDevelo** an optimal stratification model for colorectal cancer screening and reducing racial disparities in multi-center population-based studies
Early detection of colorectal neoplasms can reduce the colorectal cancer (CRC) burden by timely intervention for high-risk individuals. However, effective risk prediction models are lacking for personalized CR...
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Article
Prioritization of risk genes in colorectal cancer by integrative analysis of multi-omics data and gene networks
Genome-wide association studies (GWASs) have identified over 140 colorectal cancer (CRC)-associated loci; however, target genes at the majority of loci and underlying molecular mechanisms are poorly understood...
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Article
Open AccessGenome-wide association analysis of left ventricular imaging-derived phenotypes identifies 72 risk loci and yields genetic insights into hypertrophic cardiomyopathy
Left ventricular regional wall thickness (LVRWT) is an independent predictor of morbidity and mortality in cardiovascular diseases (CVDs). To identify specific genetic influences on individual LVRWT, we establ...
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Article
Risk SNP in a transcript of RP11-638I2.4 increases lncRNA–YY1 interaction and pancreatic cancer susceptibility
Tens of thousands of long non-coding RNAs (lncRNAs) have been identified through RNA-seq analysis, but the biological and pathological significance remains unclear. By integrating the genome-wide lncRNA data w...
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Article
Open AccessGenome-wide enhancer-gene regulatory maps link causal variants to target genes underlying human cancer risk
Genome-wide association studies have identified numerous variants associated with human complex traits, most of which reside in the non-coding regions, but biological mechanisms remain unclear. However, assign...
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Article
HSPA12A was identified as a key driver in colorectal cancer GWAS loci 10q26.12 and modulated by an enhancer–promoter interaction
Although genome-wide association studies (GWASs) have identified over 100 colorectal cancer (CRC) risk loci, an understanding of causal genes or risk variants and their biological functions in these loci remai...
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Article
Open AccessIdentification of specific susceptibility loci for the early-onset colorectal cancer
The incidence of early-onset colorectal cancer (EOCRC; patients < 50 years old) has been rising rapidly, whereas the EOCRC genetic susceptibility remains incompletely investigated. Here, we aimed to systematic...
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Article
FOXA1 of regulatory variant associated with risk of breast cancer through allele-specific enhancer in the Chinese population
FOXA1 is a pioneer transcription factor which has been established as a carcinogenic factor and can regulate the expression of downstream target genes in breast cancer. We hypothesized that genetic variants mo...
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Article
Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospective cohort study
The Coronavirus disease 2019 (COVID-19) has spread globally. Although mixed liver impairment has been reported in COVID-19 patients, the association of liver injury caused by specific subtype especially chroni...
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Recent Advances in Genetic Epidemiology of Colorectal Cancer in Chinese Population
Colorectal cancer is the most common malignant tumor in digestive system, ranks third in the incidence of cancers, but second in terms of cancer mortality all around the world. With the development of socioeco...
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Article
Open AccessClinical characteristics and risk factors of fatal patients with COVID-19: a retrospective cohort study in Wuhan, China
The coronavirus disease 2019 (COVID-19) has caused a global pandemic, resulting in considerable mortality. The risk factors, clinical treatments, especially comprehensive risk models for COVID-19 death are urg...
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Article
Identification of genetic variants in m6A modification genes associated with pancreatic cancer risk in the Chinese population
N6-Methyladenosine (m6A) is the most prevalent modification of RNA in eukaryotes, and is associated with many cellular processes and even the development of cancers. We hypothesized that single-nucleotide polymor...
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Article
Open AccessCopper alloy production in the Warring States period (475-221 BCE) of the Shu state: a metallurgical study on copper alloy objects of the Baishoulu cemetery in Chengdu, China
Many bronze objects were unearthed in the capital of the Shu state in present-day Chengdu. However, only a few metallurgical studies have been carried out on those objects. This research attempts to study the ...
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Article
Functional characterization of a low-frequency V1937I variant in FASN associated with susceptibility to esophageal squamous cell carcinoma
Metabolic reprogramming has been regarded as one of the core hallmarks of cancer and increased de novo fatty acid synthesis has been documented in multiple tumors including esophageal squamous cell carcinoma (...
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Article
Open AccessFighting and burial: the production of bronze weapons in the Shu state based on a case study of **nghelu cemetery, Chengdu, China
This article discusses the bronze weapons discovered in the **nghelu cemetery of Chengdu, China in order to study the production of bronze weapons in the Shu state. Metallographic microscopy, inductively coupl...
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Article
LINC01149 variant modulates MICA expression that facilitates hepatitis B virus spontaneous recovery but increases hepatocellular carcinoma risk
Interpreting disease-causing variants, especially in noncoding regions by genome-wide association studies (GWAS), has become one of the most challenging and demanding tasks. We hypothesized that functional lnc...
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Article
Three functional variants were identified to affect RPS24 expression and significantly associated with risk of colorectal cancer
GWAS-identified 10q22.3 loci with lead SNP rs704017 are significantly associated with CRC risk in both Asian and European populations. However, the functional mechanism of this region is unclear. In this study...
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Article
Open AccessExome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations
Germline coding variants have not been systematically investigated for pancreatic ductal adenocarcinoma (PDAC). Here we report an exome-wide investigation using the Illumina Human Exome Beadchip with 943 PDAC ...
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Article
Experimental and Analytical Study of Eccentrically Braced Frames Combined with High-Strength Steel
In the structure of high-strength steel composite eccentrically braced steel frames (HSS–EBFs), the links and braces are made of Q345 steel, while the non-energy-dissipation segments (columns and beams) are m...
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Article
Exome-wide analyses identify low-frequency variant in CYP26B1 and additional coding variants associated with esophageal squamous cell carcinoma
Genome-wide association studies have identified common variants associated with risk of esophageal squamous cell carcinoma (ESCC). However, these common variants cannot explain all heritability of ESCC. Here w...
