7 Result(s)
within
Jianbing Mu
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessEstablishment and validation of a plasma oncofetal chondroitin sulfated proteoglycan for pan-cancer detection
Various biomarkers targeting cell-free DNA (cfDNA) and circulating proteins have been tested for pan-cancer detection. Oncofetal chondroitin sulfate (ofCS), which distinctively modifies proteoglycans (PGs) of ...
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Article
Open AccessPlasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross
Mainstay treatment for Plasmodium vivax malaria has long relied on chloroquine (CQ) against blood-stage parasites plus primaquine against dormant liver-stage forms (hypnozoites), however drug resistance confronts...
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Open AccessMutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite’s food vacuole and alter drug sensitivities
Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, are the major determinant of chloroquine resistance in this lethal human malaria parasite. Here, we describe P. falciparum lines s...
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PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum
The malaria parasite Plasmodium falciparum escapes immune detection by expressing one of 60 antigenically distinct var genes at any one time during the course of infection: here it is shown that the P. falciparum
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Correction: Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum
Nature 418, 323–326 (2002). It has been drawn to our attention that the 3D7 parasite, labelled as an African parasite in our Letter, was initially isolated from The Netherlands, although we have some genetic e...
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Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum
The Malaria's Eve hypothesis, proposing a severe recent population bottleneck (about 3,000–5,000 years ago) of the human malaria parasite Plasmodium falciparum, has prompted a debate about the origin and evolutio...
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Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum
Widespread use of antimalarial agents can profoundly influence the evolution of the human malaria parasite Plasmodium falciparum. Recent selective sweeps for drug-resistant genotypes may have restricted the genet...
