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145 Result(s)
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Article
Open AccessBlack TiO2-based nanoparticles as Toll-like receptor stimulator delivery system for enhanced photothermal-immunotherapy of pancreatic cancer
The tumor-specific immune responses, essential for removing residual lesions and preventing tumor metastases, can be stimulated by tumor-associated antigens (TAAs) released following photothermal therapy (PTT)...
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Open AccessPharmacokinetics and pharmacodynamics of antibacterial peptide NZX in Staphylococcus aureus mastitis mouse model
Staphylococcus aureus is associated with dairy mastitis, which causes serious economic losses to dairy farming industry. Antibacterial peptide NZX showed good antibacterial activity against S. aureus. This study ...
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Open AccessConsolidation chemotherapy after definitive concurrent chemoradiotherapy in patients with inoperable esophageal squamous cell carcinoma: a multicenter non-inferiority phase III randomized clinical trial
Definitive concurrent chemoradiotherapy (dCCRT) is the gold standard for the treatment of locally advanced esophageal squamous cell carcinoma (ESCC). However, the potential benefits of consolidation chemothera...
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Open AccessOverview of Research Progress on Numerical Simulation Methods for Turbulent Flows Around Underwater Vehicles
In this paper, we present an overview of numerical simulation methods for the flow around typical underwater vehicles at high Reynolds numbers, which highlights the dominant flow structures in different region...
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Open AccessPractical solutions in fully homomorphic encryption: a survey analyzing existing acceleration methods
Fully homomorphic encryption (FHE) has experienced significant development and continuous breakthroughs in theory, enabling its widespread application in various fields, like outsourcing computation and secure...
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Open AccessExpression and characterization of the new antimicrobial peptide AP138L-arg26 anti Staphylococcus aureus
The low activity and yield of antimicrobial peptides (AMPs) are pressing problems. The improvement of activity and yield through modification and heterologous expression, a potential way to solve the problem, ...
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Open AccessThe association between jaundice and poorly differentiated pancreatic neuroendocrine neoplasms (Ki67 index > 55.0%)
Jaundice occurs in some pancreatic disease. However, its occurrences and role in pancreatic neuroendocrine neoplasms (PNENs) has not been well studied. In this study we showed the association between jaundice ...
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Open AccessCalcium phosphate cement promotes the stability of osteoporotic lumbar pedicle screw by enhancer-injecters with different number of holes
This study aimed to compare whether Calcium phosphate cement (CPC) promotes the stability of osteoporotic lumbar pedicle screw by enhancer-injecters with different number of holes.
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Open AccessA cleavable chimeric peptide with targeting and killing domains enhances LPS neutralization and antibacterial properties against multi-drug resistant E. coli
Pathogenic Escherichia coli is one of the most common causes of diarrhea diseases and its characteristic component of the outer membrane-lipopolysaccharide (LPS) is a major inducer of sepsis. Few drugs have been ...
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Open AccessSuppressed Akt/GSK-3β/β-catenin signaling contributes to excessive adipogenesis of fibro-adipogenic progenitors after rotator cuff tears
Muscular fatty infiltration is a common and troublesome pathology after rotator cuff tears (RCT), which mainly derives from fibro-adipogenic progenitors (FAPs). Compared to the RCT, fatty infiltration is not s...
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Article
Open AccessGenome mining shows that retroviruses are pervasively invading vertebrate genomes
Endogenous retroviruses (ERVs) record past retroviral infections, providing molecular archives for interrogating the evolution of retroviruses and retrovirus-host interaction. However, the vast majority of ERV...
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Open AccessAssociation of cardiovascular health at old age with all-cause mortality: a prospective cohort study in China
Cardiovascular disease has become the leading cause of death worldwide, but there is a lack of data on whether cardiovascular health (CVH) is associated with elderly mortality in China. We investigated the rel...
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Open AccessImpact of frequent intradialytic hypotension on quality of life in patients undergoing hemodialysis
Intradialytic hypotension (IDH) is frequently accompanied by symptoms of nausea, dizziness, fatigue, muscle spasm, and arrhythmia, which can adversely impact the daily lives of patients who undergo hemodialysi...
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Open AccessSpatial–temporal variation of extreme precipitation in the Yellow–Huai–Hai–Yangtze Basin of China
Climate warming leads to frequent extreme precipitation events, which is a prominent manifestation of the variation of the global water cycle. In this study, data from 1842 meteorological stations in the Huang...
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Lactoferrin, a Great Wall of host-defence?
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Open AccessExploring best-matched embedding model and classifier for charging-pile fault diagnosis
The continuous increase of electric vehicles is being facilitating the large-scale distributed charging-pile deployment. It is crucial to guarantee normal operation of charging piles, resulting in the importan...
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Open AccessThe prognostic role of the AST/ALT ratio in hepatocellular carcinoma patients receiving thermal ablation combined with simultaneous TACE
To evaluate the prognostic value of the pre-treatment aspartate transaminase (AST)/alanine transaminase (ALT) ratio in hepatocellular carcinoma (HCC) patients receiving radiofrequency ablation (RFA)/microwave ...
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Open AccessAn autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin loo**
Genetic sharing is extensively observed for autoimmune diseases, but the causal variants and their underlying molecular mechanisms remain largely unknown. Through systematic investigation of autoimmune disease...
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Open AccessInternet-based self-help intervention for procrastination: randomized control group trial protocol
Procrastination or “postponing until later” is a common phenomenon defined as the intentional delay in partaking in and finishing important activities despite negative outcomes potentially outweighing the posi...
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Open AccessPhysician education on World Asthma Day aids in disease management during the COVID-19
Anxiety and depression can negatively affect the management of asthma. The study aimed to assess the psychosocial effects of asthma patients during COVID-19 and analyze potential risk factors and interventions.