53 Result(s)
within
JianHua Wang
English
Biotechnology
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Article
Open AccessPharmacokinetics and pharmacodynamics of antibacterial peptide NZX in Staphylococcus aureus mastitis mouse model
Staphylococcus aureus is associated with dairy mastitis, which causes serious economic losses to dairy farming industry. Antibacterial peptide NZX showed good antibacterial activity against S. aureus. This study ...
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Article
Open AccessExpression and characterization of the new antimicrobial peptide AP138L-arg26 anti Staphylococcus aureus
The low activity and yield of antimicrobial peptides (AMPs) are pressing problems. The improvement of activity and yield through modification and heterologous expression, a potential way to solve the problem, ...
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Article
Combined population transcriptomic and genomic analysis reveals cis-regulatory differentiation of non-coding RNAs in maize
Long intergenic non-coding RNA (lincRNA), cis-acting expression quantitative trait locus (cis-eQTL), maize, regulatory evolution.
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Article
Open AccessIGF1 receptor-targeted black TiO2 nanoprobes for MRI-guided synergetic photothermal-chemotherapy in drug resistant pancreatic tumor
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest malignant tumors with features of matrix barrier caused poor drug permeability, and susceptibility to drug resistance. Herein, a PDAC and its stro...
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Article
Antibacterial peptide NZ2114-loaded hydrogel accelerates Staphylococcus aureus-infected wound healing
Wound infection caused by Staphylococcus aureus (S. aureus) is a great challenge which has caused significant burden and economic loss to the medical system. NZ2114, a plectasin-derived peptide, is an antibacteri...
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Resistance response to Arenicin derivatives in Escherichia coli
The rising prevalence of antibiotic resistance poses the greatest health threats. Antimicrobial peptides (AMPs) are regarded as the potentially effective therapy. To avoid current crisis of antibiotic resistan...
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Open AccessEvaluating effect of metallic ions on aggregation behavior of β-amyloid peptides by atomic force microscope and surface-enhanced Raman Scattering
Excessive aggregation of β-amyloid peptides (Aβ) is regarded as the hallmark of Alzheimer’s disease. Exploring the underlying mechanism regulating Aβ aggregation remains challenging and investigating aggregati...
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Article
A study on fungal defensin against multidrug-resistant Clostridium perfringens and its treatment on infected poultry
In the present study, we aimed to investigate the antibacterial activity and mechanisms of plectasin-derived peptide NZ2114 in vitro and its therapeutic effects in vivo on broilers challenged with Clostridium per...
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Fatty acid modified-antimicrobial peptide analogues with potent antimicrobial activity and topical therapeutic efficacy against Staphylococcus hyicus
There is an urgent need to explore new antimicrobial agents due to the looming threat of bacteria resistance. Bovine lactoferricin (LfcinB), as a multifunctional peptide, has the potential to be a new active d...
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Article
Open AccessStructural design of tetravalent T-cell engaging bispecific antibodies: improve developability by engineering disulfide bonds
Since the advances in protein engineering and manufacture, over the last 30 years, antibody-based immunotherapeutic has become a powerful strategy to treat diseases. The T-cell engaging bispecific antibody (Bs...
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Open AccessSeed biostimulant Bacillus sp. MGW9 improves the salt tolerance of maize during seed germination
Crop performance is seriously affected by high salt concentrations in soils. To develop improved seed pre-sowing treatment technologies, it is crucial to improve the salt tolerance of seed germination. Here, w...
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Article
Potent intracellular antibacterial activity of a marine peptide-N6NH2 and its D-enantiomer against multidrug-resistant Aeromonas veronii
Aeromonas veronii can cause a variety of diseases such as sepsis in humans and animals. However, there has been no effective way to eradicate A. veronii. In this study, the intracellular antibacterial activities ...
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Open AccessPedigree-based genetic dissection of quantitative loci for seed quality and yield characters in improved soybean
As soybean plays an indispensable role in the supply of vegetable oil and protein, balancing the relationship between seed quality and yield traits according to human demand has become an important breeding go...
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Article
A recombinant fungal defensin-like peptide-P2 combats Streptococcus dysgalactiae and biofilms
Streptococcus dysgalactiae, considered one of the main pathogens that causes bovine mastitis, is a serious threat to humans and animals. However, the excessive use of antibiotics and the characteristic of S. dysg...
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Therapeutic potential of a designed CSαβ peptide ID13 in Staphylococcus aureus-induced endometritis of mice
Staphylococcus aureus is a common pathogen that can cause clinical and subclinical endometritis in humans and animals. In this study, a designed CSαβ peptide ID13 from DLP4 exhibited high stable antibacterial act...
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A new high-yielding antimicrobial peptide NZX and its antibacterial activity against Staphylococcus hyicus in vitro/vivo
Staphylococcus hyicus, considered as a leading pathogen of exudative epidermitis, is a serious threat to humans and animals. The emergency of bacterial resistance to antibiotics, especially in human and animal he...
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Article
Dynamics of nitrogen transformation and bacterial community with different aeration depths in malodorous river
In this research, the dynamics of nitrogen transformation and bacterial community in malodorous river were investigated with different aeration depths. Computational flow dynamics (CFD) and Reynolds number (Re...
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Article
Biodegradation of mycotoxin fumonisin B1 by a novel bacterial consortium SAAS79
Fumonisin B1 (FB1) contamination in cereals and cereal products remains an important aspect of food safety because of its wide distribution and the potential health hazard. However, only a few microorganisms h...
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Article
A recombinant fungal defensin-like peptide-P2 combats multidrug-resistant Staphylococcus aureus and biofilms
There is an urgent need to discover new active drugs to combat methicillin-resistant Staphylococcus aureus, which is a serious threat to humans and animals and incompletely eliminated by antibiotics due to its in...
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QTL identification and epistatic effect analysis of seed size- and weight-related traits in Zea mays L
Seed size and weight are two seed physical traits showing high correlation to seed quality and grain yield. Here, we employed a maize F2:3 population developed from a cross between inbred line 220 (herein named L...
