766 Result(s)

Article

Integrative metagenomic, transcriptomic, and proteomic analysis reveal the microbiota-host interplay in early-stage lung adenocarcinoma among non-smokers

The incidence of early-stage lung adenocarcinoma (ES-LUAD) is steadily increasing among non-smokers. Previous research has identified dysbiosis in the gut microbiota of patients with lung cancer. However, the ...

Yaohui Sun, Zhiming Gan, **ao** Wang, Jian Liu… in Journal of Translational Medicine (2024)

Article

The Role of the Intestinal Flora and Its Derivatives in Neurocognitive Disorders: A Narrative Review from Surgical Perspective

Perioperative neurocognitive dysfunction is a significant concern for population health, impacting postoperative recovery and increasing the financial burden on patients. With an increasing number of surgical ...

Jian Huang, Tian-Shou Qin, Yun Bo, Yu-** Li, Rong-Sheng Liu… in Molecular Neurobiology (2024)

Article

Assessment of the influence of levees along Yangtze River on Oncomelania hupensis, the intermediate host of Schistosoma japonicum

Oncomelania hupensis is the exclusive intermediate host of Schistosoma japonicum in China. Snail control is an essential component of schistosomiasis elimination programme. With 70 years of continuous efforts, th...

Shen Chen, Yin-Long Li, Lei Duan, Jian-Bing Liu, Jie Zhou… in Parasites & Vectors (2024)

Article

Cultivation of novel Atribacterota from oil well provides new insight into their diversity, ecology, and evolution in anoxic, carbon-rich environments

The Atribacterota are widely distributed in the subsurface biosphere. Recently, the first Atribacterota isolate was described and the number of Atribacterota genome sequences retrieved from environmental samples ...

Jian-Yu Jiao, Shi-Chun Ma, Nimaichand Salam, Zhuo Zhou, Zheng-Han Lian, Li Fu… in Microbiome (2024)

Article

Understanding the genetic complexity of puberty timing across the allele frequency spectrum

Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women, identifying 1,080 signals for age at menarche. Collectively, th...

Katherine A. Kentistou, Lena R. Kaisinger, Stasa Stankovic, Marc Vaudel… in Nature Genetics (2024)

Article

Correction: Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson’s disease

Yan-fang Hou, Chang Shan, Si-yue Zhuang, Qian-qian Zhuang, Arijit Ghosh… in Microbiome (2024)

Article

Wnt5a-mediated autophagy contributes to the epithelial-mesenchymal transition of human bronchial epithelial cells during asthma

The epithelial-mesenchymal transition (EMT) of human bronchial epithelial cells (HBECs) is essential for airway remodeling during asthma. Wnt5a has been implicated in various lung diseases, while its role in t...

Yu-Biao Liu, **ao-Hua Tan, Hui-Hui Yang, **-Tong Yang, Chen-Yu Zhang… in Molecular Medicine (2024)

Article

A Cysteinyl-tRNA Synthetase Mutation Causes Novel Autosomal-Dominant Inheritance of a Parkinsonism/Spinocerebellar-Ataxia Complex

This study aimed to identify possible pathogenic genes in a 90-member family with a rare combination of multiple neurodegenerative disease phenotypes, which has not been depicted by the known neurodegenerative...

Han-Kui Liu, Hong-Lin Hao, Hui You, Feng Feng, **u-Hong Qi… in Neuroscience Bulletin (2024)

Article

DUSP5 regulated by YTHDF1-mediated m6A modification promotes epithelial-mesenchymal transition and EGFR-TKI resistance via the TGF-β/Smad signaling pathway in lung adenocarcinoma

Lung adenocarcinoma (LUAD) patients have a dismal survival rate because of cancer metastasis and drug resistance. The study aims to identify the genes that concurrently modulate EMT, metastasis and EGFR-TKI re...

Weina Fan, Ying **ng, Shi Yan, Wei Liu, **feng Ning… in Cancer Cell International (2024)

Article

γδ T cells and the PD-1/PD-L1 axis: a love–hate relationship in the tumor microenvironment

Gamma delta (γδ) T cells demonstrate strong cytotoxicity against diverse cancer cell types in an MHC-independent manner, rendering them promising contenders for cancer therapy. Although amplification and adopt...

Jian Liu, Min Wu, Yifan Yang, Zixuan Wang, Shan He… in Journal of Translational Medicine (2024)

Article

YTHDF1’s grip on CRC vasculature: insights into LINC01106 and miR-449b-5p-VEGFA axis

Investigating the unexplored territory of lncRNA m6A modification in colorectal cancer (CRC) vasculature, this study focuses on LINC01106 and YTHDF1.

Rui-ting Ma, Yuanyuan Wang, Feng Ji, Jian-nan Chen… in Cancer Cell International (2024)

Article

Association between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer

Emotional distress (ED), commonly characterized by symptoms of depression and/or anxiety, is prevalent in patients with cancer. Preclinical studies suggest that ED can impair antitumor immune responses, but fe...

Yue Zeng, Chun-Hong Hu, Yi-Zheng Li, Jian-Song Zhou, Shu-**ng Wang… in Nature Medicine (2024)

Article

HBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis

The root of Aconitum carmichaelii Debx. (Fuzi) is an herbal medicine used in China that exerts significant efficacy in rescuing patients from severe diseases. A key toxic compound in Fuzi, aconitine (AC), could t...

Ya-juan Guo, **g-**g Yao, Zhen-zhen Guo, Ming Ding… in Acta Pharmacologica Sinica (2024)

Article

Quercetin promotes the proportion and maturation of NK cells by binding to MYH9 and improves cognitive functions in aged mice

Quercetin is a flavonol compound widely distributed in plants that possesses diverse biological properties, including antioxidative, anti-inflammatory, anticancer, neuroprotective and senescent cell-clearing a...

Tingting Su, Haitao Shen, Mengyuan He, Shanshan Yang, Xue Gong… in Immunity & Ageing (2024)

Article

Prevalence of metabolic syndrome among patients with hepatocellular carcinoma of different etiologies: a retrospective study

This study compared the prevalences of metabolic syndrome and of cardiac or kidney comorbidities among patients with hepatocellular carcinoma (HCC) associated with metabolic dysfunction-related fatty liver dis...

Da-Long Yang, Shao-** Liu, Hong-Liang Wang, Jian-Rong Li… in Infectious Agents and Cancer (2024)

Article

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10⁻⁸) from the largest single-stage blood pressure (BP...

Jacob M. Keaton, Zoha Kamali, Tian **e, Ahmad Vaez, Ariel Williams… in Nature Genetics (2024)

Article

Measurable residual disease monitoring by ddPCR in the early posttransplant period complements the traditional MFC method to predict relapse after HSCT in AML/MDS: a multicenter retrospective study

Droplet digital PCR (ddPCR) is widely applied to monitor measurable residual disease (MRD). However, there are limited studies on the feasibility of ddPCR-MRD monitoring after allogeneic hematopoietic stem cel...

Weihao Chen, **gtao Huang, Yeqian Zhao, Luo Huang… in Journal of Translational Medicine (2024)

Article

Identification and Validation of Basement Membrane Related LncRNA Signatures as a Novel Prognostic Model for Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is a significant cancer with limited treatments and a poor prognosis, with the basement membrane (BM) playing a crucial role in its initiation and growth. This study utilized dat...

Xuyang Liu, Chao Lv, Jian Zheng, **g**g **ao, Nan He, Jun Du… in Biochemical Genetics (2024)

Article

Blocking the MIF-CD74 axis augments radiotherapy efficacy for brain metastasis in NSCLC via synergistically promoting microglia M1 polarization

Brain metastasis is one of the main causes of recurrence and death in non-small cell lung cancer (NSCLC). Although radiotherapy is the main local therapy for brain metastasis, it is inevitable that some cancer...

Lichao Liu, Jian Wang, Ying Wang… in Journal of Experimental & Clinical Cancer … (2024)

Article

Refined risk stratification helps guiding transplantation choice in adult BCR::ABL1-positive acute lymphoblastic leukemia

Cheng Wang, Jianfeng Li, Weiyang Liu, Lingling Zhao, Han Yan… in Blood Cancer Journal (2024)