54 Result(s)
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Open AccessFTO deficiency in older livers exacerbates ferroptosis during ischaemia/reperfusion injury by upregulating ACSL4 and TFRC
Older livers are more prone to hepatic ischaemia/reperfusion injury (HIRI), which severely limits their utilization in liver transplantation. The potential mechanism remains unclear. Here, we demonstrate older...
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Open AccessDGPRI, a new liver fibrosis assessment index, predicts recurrence of AFP-negative hepatocellular carcinoma after hepatic resection: a single-center retrospective study
Although patients with alpha-fetoprotein-negative hepatocellular carcinoma (AFPNHCC) have a favorable prognosis, a high risk of postoperative recurrence remains. We developed and validated a novel liver fibros...
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Open AccessSurgical treatment improves overall survival of hepatocellular carcinoma with extrahepatic metastases after conversion therapy: a multicenter retrospective study
Systemic therapy is typically the primary treatment choice for hepatocellular carcinoma (HCC) patients with extrahepatic metastases. Some patients may achieve partial response (PR) or complete response (CR) wi...
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Open AccessMetabolomic profiles of sleep-disordered breathing are associated with hypertension and diabetes mellitus development
Sleep-disordered breathing (SDB) is a prevalent disorder characterized by recurrent episodic upper airway obstruction. Using data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we apply ...
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Open AccessX-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association met...
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Open AccessMethod comparison and estimation of causal effects of insomnia on health outcomes in a survey sampled population
Applying causal inference methods, such as weighting and matching methods, to a survey sampled population requires properly incorporating the survey weights and design to obtain effect estimates that are repre...
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Open AccessA high-sensitivity rotatable 3D displacement sensor
Aiming at the problems of low sensitivity and low accuracy caused by the displacement transfer mechanism of three displacement sensors used simultaneously in the 3D displacement monitoring of seismic isolation...
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Open AccessInteraction analysis of ancestry-enriched variants with APOE-ɛ4 on MCI in the Study of Latinos-Investigation of Neurocognitive Aging
APOE-ɛ4 risk on Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD) differs between race/ethnic groups, presumably due to ancestral genomic background surrounding the APOE locus. We studied whether Afric...
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Open AccessSmall molecule targeting long noncoding RNA GAS5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model
Shifts in normal aging set stage for neurodegeneration and dementia affecting 1 in 10 adults. The study demonstrates that lncRNA GAS5 is decreased in aged and Alzheimer’s disease brain. The role and targets of...
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Open AccessDevelopment and validation of a metabolite index for obstructive sleep apnea across race/ethnicities
Obstructive sleep apnea (OSA) is a common disorder characterized by recurrent episodes of upper airway obstruction during sleep resulting in oxygen desaturation and sleep fragmentation, and associated with inc...
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Open AccessGPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression
Regulatory T cells (Tregs) are critically involved in neovascularization, an important compensatory mechanism in peripheral artery disease. The contribution of G protein coupled receptor 174 (GPR174), which is...
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Open AccessRational design of a sensitivity-enhanced tracer for discovering efficient APC–Asef inhibitors
The adenomatous polyposis coli (APC)–Rho guanine nucleotide exchange factor 4 (Asef) protein–protein interaction (PPI) is essential for colorectal cancer metastasis, making it a promising drug target. Herein, ...
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Open AccessNestin-dependent mitochondria-ER contacts define stem Leydig cell differentiation to attenuate male reproductive ageing
Male reproductive system ageing is closely associated with deficiency in testosterone production due to loss of functional Leydig cells, which are differentiated from stem Leydig cells (SLCs). However, the rel...
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Open AccessAnti-HER2 scFv-CCL19-IL7 recombinant protein inhibited gastric tumor growth in vivo
HER-2 targeted therapies, such as monoclonal antibodies (mAbs) and CAR-T cell therapy have been applied in the treatment of various of cancers. However, the anti-HER2 CAR-T cell therapy are limited by its expe...
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Open AccessExploring phylogenetic relationships within the subgenera of Bambusa based on DNA barcodes and morphological characteristics
The genus Bambusa belongs to the subtribe Bambusinae and the subfamily Bambusoideae. The subgenera of Bambusa has not been satisfactorily circumscribed, and this remains a major taxonomic issue. Simultaneously, g...
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Open AccessSelf-regulated co-assembly of soft and hard nanoparticles
Controlled self-assembly of colloidal particles into predetermined organization facilitates the bottom-up manufacture of artificial materials with designated hierarchies and synergistically integrated function...
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Open AccessField-free topological behavior in the magnetic domain wall of ferrimagnetic GdFeCo
Exploring and controlling topological textures such as merons and skyrmions has attracted enormous interests from the perspective of fundamental research and spintronic applications. It has been predicted theo...
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Open AccessPublisher Correction: Catchment landscape components alter relationships between discharge and stream water nutrient ratios in the **tiao River Basin China
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Open AccessCatchment landscape components alter relationships between discharge and stream water nutrient ratios in the **tiao River Basin China
The terrestrial environment of a watershed is a source of potential carbon (C), nitrogen (N), and phosphorus (P) exports, and the hydrological regime provides the mechanism to turn the potential exports into r...
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Open AccessCross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2
Up to date, effective antivirals have not been widely available for treating COVID-19. In this study, we identify a dual-functional cross-linking peptide 8P9R which can inhibit the two entry pathways (endocyti...
