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Article
Open AccessNur77-IRF1 axis inhibits esophageal squamous cell carcinoma growth and improves anti-PD-1 treatment efficacy
The nuclear receptor Nur77 plays paradoxical roles in numerous cancers. However, whether Nur77 inhibits esophageal squamous cell carcinoma (ESCC) growth and affects immunological responses against ESCC has not...
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Article
Open AccessInhibition of autophagy-related protein 7 enhances anti-tumor immune response and improves efficacy of immune checkpoint blockade in microsatellite instability colorectal cancer
The efficacy of anti-PD-1 therapy is primarily hindered by the limited T-cell immune response rate and immune evasion capacity of tumor cells. Autophagy-related protein 7 (ATG7) plays an important role in auto...
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Article
Open AccessLandscape evolution in China’s key ecological function zones during 1990–2015
Landscape evolution has profound effects on ecosystems. Recently, some studies suggest that China has implemented plans leading in the greening of the world by mainly describing the changes based on satellite ...
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Article
Open AccessThe single-cell transcriptomic atlas and RORA-mediated 3D epigenomic remodeling in driving corneal epithelial differentiation
Proper differentiation of corneal epithelial cells (CECs) from limbal stem/progenitor cells (LSCs) is required for maintenance of ocular homeostasis and clear vision. Here, using a single-cell transcriptomic a...
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Article
Open AccessProtection of the marginal mandibular branches of the facial nerves by different surgical procedures in comprehensive cervical lymphadenectomy for locally advanced oral and oropharyngeal cancer: a multicenter experience
According to the different characteristics of patients and cervical lymph node metastasis of oral and oropharyngeal cancer, the marginal mandibular branches of facial nerves were treated by different surgical ...
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Article
Open AccessComprehensive 3D epigenomic maps define limbal stem/progenitor cell function and identity
The insights into how genome topology couples with epigenetic states to govern the function and identity of the corneal epithelium are poorly understood. Here, we generate a high-resolution Hi-C interaction ma...
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Article
Open AccessCore transcription regulatory circuitry orchestrates corneal epithelial homeostasis
Adult stem cell identity, plasticity, and homeostasis are precisely orchestrated by lineage-restricted epigenetic and transcriptional regulatory networks. Here, by integrating super-enhancer and chromatin acce...
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Article
Open AccessLoss of FOXC1 contributes to the corneal epithelial fate switch and pathogenesis
Forkhead box C1 (FOXC1) is required for neural crest and ocular development, and mutations in FOXC1 lead to inherited Axenfeld–Rieger syndrome. Here, we find that FOXC1 and paired box 6 (PAX6) are co-expressed in...
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Article
Open AccessLong Noncoding RNA CTC Inhibits Proliferation and Invasion by Targeting miR-146 to Regulate KIT in Papillary Thyroid Carcinoma
Several lines of evidence have shown that long non-coding RNAs (lncRNAs) are dysregulated in many diseases. Nevertheless, the biological relevance of the lncRNAs in papillary thyroid carcinoma (PTC) has not be...
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Article
Open AccessRisk factors for bile leakage after primary closure following laparoscopic common bile duct exploration: a retrospective cohort study
Primary closure following laparoscopic common bile duct exploration (LCBDE) has been widely adopted because of the efficacy and safety in treatment of common bile duct (CBD) stones. However, the risk factors f...
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Article
Open AccessA reciprocating motion-driven rotation mechanism for the ATP synthase
The ATP synthase (having a typical subunit composition of α3β3γδεab2c8-15) employs an intriguing rotary mechanism for the generation of ATP from ADP and Pi, using energy stored in a transmembrane proton gradient....
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Article
Open AccessAn automated and simple method for brain MR image extraction
The extraction of brain tissue from magnetic resonance head images, is an important image processing step for the analyses of neuroimage data. The authors have developed an automated and simple brain extractio...
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Article
Open AccessBanknote Image Retrieval Using Rotated Quaternion Wavelet Filters
A new method of banknote image retrieval is proposed by using new set of rotated quaternion wavelet filters (RQWF) and standard quaternion wavelet transform (QWT) jointly. The robust and rotationally invariant...
