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    Article

    Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic metabolism of macrophages

    Liver X receptors (LXRs) which link lipid metabolism and inflammation, were overexpressed in experimental rheumatoid arthritis (RA) rats as observed in our previous studies, while suppression of LXRα by silybi...

    De-chong Zheng, Jia-qin Hu, Chu-tian Mai, Li Huang, Hua Zhou… in Acta Pharmacologica Sinica (2024)

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    Article

    Sinomenine ameliorates collagen-induced arthritis in mice by targeting GBP5 and regulating the P2X7 receptor to suppress NLRP3-related signaling pathways

    Sinomenine (SIN) is an isoquinoline alkaloid isolated from Sinomenii Caulis, a traditional Chinese medicine used to treat rheumatoid arthritis (RA). Clinical trials have shown that SIN has comparable efficacy ...

    Juan-min Li, Hai-shan Deng, Yun-da Yao, Wei-ting Wang… in Acta Pharmacologica Sinica (2023)