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    Shikonin attenuates hyperhomocysteinemia-induced CD4+ T cell inflammatory activation and atherosclerosis in ApoE−/− mice by metabolic suppression

    T cell metabolic activation plays a crucial role in inflammation of atherosclerosis. Shikonin (SKN), a natural naphthoquinone with anti-inflammatory activity, has shown to exert cardioprotective effects, but t...

    Si-lin Lü, Guo-hui Dang, Jia-cheng Deng, Hui-ying Liu, Bo Liu… in Acta Pharmacologica Sinica (2020)