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248 Result(s)
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Article
The Yeast Genome Directory
This directory was made possible by a unique international collaboration between the 633 scientists whose names appear below. It represents both the first published description of the complete sequence of most...
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The structural basis for activation of plant immunity by bacterial effector protein AvrPto
Many microbial plant pathogens have evolved effector proteins that enhance virulence by neutralizing host-plant defences. Plants have countered by develo** highly specific resistance proteins that recognize ...
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Multifunctional nanoparticles as coupled contrast agents
Engineering compact imaging probes with highly integrated modalities is a key focus in bionanotechnology and will have profound impact on molecular diagnostics, imaging and therapeutics. However, combining mul...
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Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
Using large-scale exome sequencing, Andrew Futreal and colleagues have identified a second frequently mutated gene (after VHL) in clear cell renal cell carcinomas, the most frequent type of kidney cancer. PBRM1, ...
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Crystal structure of a membrane-embedded H+-translocating pyrophosphatase
A model for the coupling of proton pum** and pyrophosphatase hydrolysis is proposed.
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Open AccessEmergence of grou** in multi-resource minority game dynamics
Complex systems arising in a modern society typically have many resources and strategies available for their dynamical evolutions. To explore quantitatively the behaviors of such systems, we propose a class of...
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Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin
Chronic inflammation is a feature of the ageing brain and some neurodegenerative diseases; the authors show that astrocytes normally suppress neuroinflammation through activation of their DRD2 receptor by CRYA...
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Open AccessPhenothiazine Derivative-Accelerated Microbial Extracellular Electron Transfer in Bioelectrochemical System
In bioelectrochemical system (BES) the extracellular electron transfer (EET) from bacteria to anode electrode is recognized as a crucial step that governs the anodic reaction efficiency. Here, we report a nove...
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Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing
Single-cell RNA sequencing and weighted gene co-expression network analysis are used to study transcriptome change in pre-implantation embryos and oocytes; this reveals a conserved genetic program between huma...
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Open AccessMaternal depressive symptoms related to Epstein-Barr virus reactivation in late pregnancy
We examined the relationship between maternal depressive symptoms in late pregnancy and Epstein-Barr virus reactivation before delivery. In this prospective observational study, prevalence of Epstein-Barr viru...
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Open AccessHyperthyroidism is a Risk Factor for Develo** Adhesive Capsulitis of the Shoulder: A Nationwide Longitudinal Population-Based Study
The purpose of this study was to investigate the prevalence and risk of adhesive capsulitis among hyperthyroidism patients. The data were obtained from the Longitudinal Health Insurance Database 2005 (LHID 200...
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Unstacked double-layer templated graphene for high-rate lithium–sulphur batteries
Preventing the stacking of graphene is essential to exploiting its full potential in energy-storage applications. The introduction of spacers into graphene layers always results in a change in the intrinsic pr...
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Open AccessRisk of Stroke in Patients with Rheumatism: A Nationwide Longitudinal Population-based Study
The aim of this study was to investigate rheumatoid arthritis (RA) and systemic lupus erythematous (SLE) as risk factors for stroke. The study was analyzed by Using the Taiwan Longitudinal Health Insurance Dat...
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Open AccessFluorinated Graphene as High Performance Dielectric Materials and the Applications for Graphene Nanoelectronics
There is broad interest in surface functionalization of 2D materials and its related applications. In this work, we present a novel graphene layer transistor fabricated by introducing fluorinated graphene (flu...
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Open AccessA graphene quantum dot photodynamic therapy agent with high singlet oxygen generation
Clinical applications of current photodynamic therapy (PDT) agents are often limited by their low singlet oxygen (1O2) quantum yields, as well as by photobleaching and poor biocompatibility. Here we present a new...
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Open AccessMicrobial communities evolve faster in extreme environments
Evolutionary analysis of microbes at the community level represents a new research avenue linking ecological patterns to evolutionary processes, but remains insufficiently studied. Here we report a relative ev...
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Open AccessGenome-wide DNA Methylation Profiles and Their Relationships with mRNA and the microRNA Transcriptome in Bovine Muscle Tissue (Bos taurine)
DNA methylation is a key epigenetic modification in mammals and plays important roles in muscle development. We sampled longissimus dorsi muscle (LDM) from a well-known elite native breed of Chinese Qinchuan catt...
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Open AccessUniversal flux-fluctuation law in small systems
The relation between flux and fluctuation is fundamental to complex physical systems that support and transport flows. A recently obtained law predicts monotonous enhancement of fluctuation as the average flux...
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Open AccessEpidemiological and Etiological Characteristics of Hand, Foot and Mouth Disease in Henan, China, 2008–2013
Hand, foot and mouth disease (HFMD) is a common childhood illness caused by enteroviruses. HFMD outbreaks and reported cases have sharply increased in China since 2008. Epidemiological and clinical data of HFM...
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Open AccessA Nomogram for Predicting the Benefit of Adjuvant Cytokine-Induced Killer Cell Immunotherapy in Patients with Hepatocellular Carcinoma
The benefits of adjuvant cytokine-induced killer (CIK) cell immunotherapy for hepatocellular carcinoma (HCC) remain mixed among patients. Here, we constructed a prognostic nomogram to enable individualized pre...