16 Result(s)
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Open AccessAuthor Correction: In vivo silencing of amphiregulin by a novel effective Self-Assembled-Micelle inhibitory RNA ameliorates renal fibrosis via inhibition of EGFR signals
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Open AccessHigher harmonics in planar Hall effect induced by cluster magnetic multipoles
Antiferromagnetic (AFM) materials are attracting tremendous attention due to their spintronic applications and associated novel topological phenomena. However, detecting and identifying the spin configurations...
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Open AccessAuthor Correction: Prime editor-mediated correction of a pathogenic mutation in purebred dogs
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Open AccessPrime editor-mediated correction of a pathogenic mutation in purebred dogs
Canine hip dysplasia (HD) is a multifactorial disease caused by interactions between genetic and environmental factors. HD, which mainly occurs in medium- to large-sized dogs, is a disease that causes severe p...
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Open AccessIn vivo silencing of amphiregulin by a novel effective Self-Assembled-Micelle inhibitory RNA ameliorates renal fibrosis via inhibition of EGFR signals
Amphiregulin (AREG) is a transmembrane glycoprotein recently implicated in kidney fibrosis. Previously, we reported that the AREG-targeting Self-Assembled-Micelle inhibitory RNA (SAMiRNA-AREG) alleviated fibro...
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Open AccessDivalent cation-induced conformational changes of influenza virus hemagglutinin
Divalent cations Cu2+ and Zn2+ can prevent the viral growth in mammalian cells during influenza infection, and viral titers decrease significantly on a copper surface. The underlying mechanisms include DNA damage...
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Open AccessAge-adjusted global glomerulosclerosis predicts renal progression more accurately in patients with IgA nephropathy
The Oxford classification was developed to predict the outcome of IgA nephropathy (IgAN). Based on the upper reference limit (95th percentile) for the number of globally sclerotic glomeruli (GSG) expected on biop...
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Open AccessAngiotensin II-mediated MYH9 downregulation causes structural and functional podocyte injury in diabetic kidney disease
MYH9, a widely expressed gene encoding nonmuscle myosin heavy chain, is also expressed in podocytes and is associated with glomerular pathophysiology. However, the mechanisms underlying MYH9-related glomerular...
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Open AccessMorphological Evaluation of Meta-stable Oligomers of α-Synuclein with Small-Angle Neutron Scattering
Amyloidogenesis of α-synuclein (αS) is considered to be a pathological phenomenon related to Parkinson’s disease (PD). As a key component to reveal the fibrillation mechanism and toxicity, we have investigated...
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Open AccessDispersion-Solvent Control of Ionomer Aggregation in a Polymer Electrolyte Membrane Fuel Cell
In this study, we examined the influence of the dispersion solvent in three dipropylene-glycol/water (DPG/water) mixtures, with DPG contents of 0, 50, and 100 wt%, on ionomer morphology and distribution, using...
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Open AccessAuthor Correction: Supersaturation-controlled microcrystallization and visualization analysis for serial femtosecond crystallography
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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Open AccessSupersaturation-controlled microcrystallization and visualization analysis for serial femtosecond crystallography
Time-resolved serial femtosecond crystallography with X-ray free electron laser (XFEL) holds the potential to view fast reactions occurring at near-physiological temperature. However, production and characteri...
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Open AccessTransparent Displays Utilizing Nanopatterned Quantum Dot Films
We report the realization of a transparent display using glass covered by a nanopatterned quantum dot (QD) film with good transmittance. The film was fabricated by nanoimprint lithography (NIL) and spin coatin...
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Open AccessApplication of galangin, an active component of Alpinia officinarum Hance (Zingiberaceae), for use in drug-eluting stents
In clinical pathology, stent interposition is used to treat vascular disease but can lead to restenosis. Drug-eluting stents (DES) are most commonly used to suppress restenosis but can also have side effects. ...
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Open AccessConformational modulation of influenza virus hemagglutinin: characterization and in vivo efficacy of monomeric form
Mutational changes that mostly occur at the head region of hemagglutinin (HA) lead to the emergence of new epidemic influenza viruses, whereas HA antigens have been modified to generate broadly neutralizing an...
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Open AccessLarge Scale Synthesis and Light Emitting Fibers of Tailor-Made Graphene Quantum Dots
Graphene oxide (GO), which is an oxidized form of graphene, has a mixed structure consisting of graphitic crystallites of sp2 hybridized carbon and amorphous regions. In this work, we present a straightforward ro...
