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Article
Open AccessDisruption of myelin structure and oligodendrocyte maturation in a macaque model of congenital Zika infection
Zika virus (ZikV) infection during pregnancy can cause congenital Zika syndrome (CZS) and neurodevelopmental delay in infants, of which the pathogenesis remains poorly understood. We utilize an established fem...
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Article
Rectal temperature after hypoxia-ischemia predicts white matter and cortical pathology in the near-term ferret
Neonatal encephalopathy (NE) remains a common cause of infant morbidity and mortality. Neuropathological corollaries of NE associated with acute hypoxia-ischemia include a central injury pattern involving the ...
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Article
Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh syndrome
Mitochondrial diseases represent a spectrum of disorders caused by impaired mitochondrial function, ranging in severity from mortality during infancy to progressive adult-onset disease. Mitochondrial dysfuncti...
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Article
Open AccessCanagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice
Canagliflozin (Cana), a clinically important anti-diabetes drug, leads to a 14% increase in median lifespan and a 9% increase in the 90th percentile age when given to genetically heterogeneous male mice from 7...
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Article
ADAR1 mutation causes ZBP1-dependent immunopathology
The RNA-editing enzyme ADAR1 is essential for the suppression of innate immune activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by disrupting the duplex structure of e...
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Article
Validation of a geropathology grading system for aging mouse studies
An understanding of early-onset mechanisms underlying age-related changes can be obtained by evaluating changes that precede frailty and end of life using histological characterization of age-related lesions. ...
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Article
Curcumin-loaded polymeric nanoparticles for neuroprotection in neonatal rats with hypoxic-ischemic encephalopathy
Hypoxic-ischemic encephalopathy is the leading cause of permanent brain injury in term newborns and currently has no cure. Inflammatory processes play a key role in the progression of this disease and may be a...
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Article
Open AccessCorrection to: Gene-environment interaction between lead and Apolipoprotein E4 causes cognitive behavior deficits in mice
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Open AccessGene-environment interaction between lead and Apolipoprotein E4 causes cognitive behavior deficits in mice
Alzheimer’s disease (AD) is characterized by progressive cognitive decline and memory loss. Environmental factors and gene-environment interactions (GXE) may increase AD risk, accelerate cognitive decline, and...
