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Article
Open AccessConservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes
Astrocytes play important roles in neurological disorders such as stroke, injury, and neurodegeneration. Most knowledge on astrocyte biology is based on studies of mouse models and the similarities and differe...
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Article
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia
Identifying the mechanisms through which genetic risk causes dementia is an imperative for new therapeutic development. Here, we apply a multistage, systems biology approach to elucidate the disease mechanisms...
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Article
Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation
Glycosylation is a well-known post-translational modification, but identifying specific roles for the attached glycans is often challenging. The identification and investigation of a new O-GlcNAc site on the tran...
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Article
Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags
Current methods to investigate glycosylation allow the identification of modification sites but provide limited additional information. A new strategy using polymers to label specific sugars now shows a huge v...
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Article
Chemical approaches to understanding O-GlcNAc glycosylation in the brain
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Article
Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics
