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Article
Open AccessImpact of therapeutic inhibition of oncogenic cell signaling tyrosine kinase on cell metabolism: in vivo-detectable metabolic biomarkers of inhibition
Inhibition of kinases is the ever-expanding therapeutic approach to various types of cancer. Typically, assessment of the treatment response is accomplished by standard, volumetric imaging procedures, performe...
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Article
Chimeric kinase ALK induces expression of NAMPT and selectively depends on this metabolic enzyme to sustain its own oncogenic function
As we show in this study, NAMPT, the key rate-limiting enzyme in the salvage pathway, one of the three known pathways involved in NAD synthesis, is selectively over-expressed in anaplastic T-cell lymphoma carr...
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Article
Open AccessEffect of Differences in Metabolic Activity of Melanoma Models on Response to Lonidamine plus Doxorubicin
Lonidamine (LND), a metabolic modulator, sensitizes DB-1 human melanoma to doxorubicin (DOX) chemotherapy by acidifying and de-energizing the tumor. This report compares the effects of LND on two human melanom...
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Article
Open AccessDrug repurposing for the treatment of glioblastoma multiforme
Glioblastoma Multiforme is the deadliest type of brain tumor and is characterized by very poor prognosis with a limited overall survival. Current optimal therapeutic approach has essentially remained unchanged...
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Chapter and Conference Paper
Map** the Redox State of CHOP-Treated Non-Hodgkin’s Lymphoma Xenografts in Mice
Drug treatment may alter the metabolism of cancer cells and may alter the mitochondrial redox state. Using the redox scanner that collects the fluorescence signals from both the oxidized flavoproteins (Fp) and...
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Chapter and Conference Paper
31P-MRS Studies of Melanoma Xenografts with Different Metastatic Potential
Previously we reported that three imaging methods, dynamic contrast enhanced magnetic resonance imaging (DCE-MRI), T1ρ-MRI, and ultralow temperature NADH/flavoprotein fluorescence imaging (redox scanning), could ...
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Chapter and Conference Paper
NMR Metabolic and Physiological Markers of Therapeutic Response
Identification of reliable metabolic and physiological NMR detectable markers for prediction and early detection of therapeutic response is essential to enabling NMR guided individualized therapy for cancer. B...
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Chapter and Conference Paper
Reduced Oxygenation In Diabetic Rat Kidneys Measured By T2* Weighted Magnetic Resonance Micro-Imaging
By applying invasive techniques for direct measurements of oxygen tension, we have reported decreased kidney oxygenation in experimental diabetes in rats. However, the non-invasive MRI technique utilizing the ...
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Chapter and Conference Paper
Histological Basis Of Mr/Optical Imaging Of Human Melanoma Mouse Xenografts Spanning A Range Of Metastatic Potentials
Predicting tumor aggressiveness will greatly facilitate cancer treatment. We have previously reported investigations utilizing various MR/optical imaging methods to differentiate human melanoma mouse xenograft...
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Chapter and Conference Paper
Lipoprotein Nanoplatform for Targeted Delivery of Diagnostic and Therapeutic Agents
Low-density lipoprotein (LDL) provides a highly versatile natural nanoplatform for delivery of optical and MRI contrast agents, photodynamic therapy agents and chemotherapeutic agents to normal and neoplastic ...
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Chapter and Conference Paper
Predicting Melanoma Metastatic Potential By Optical And Magnetic Resonance Imaging
Accurate prediction of tumor metastatic potential would be helpful in treatment planning and in the design of agents that modify the tumor phenotype. We report that three methods that are potentially transfera...
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Chapter
Applications of NMR Spectroscopy and Imaging to the Study of Immobilised Cell Physiology
The use of NMR spectroscopy and imaging in biology and medicine has grown dramatically over the last decade. The popularity of these magnetic resonance methods stems directly from the fact that they are non-in...
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Chapter
Effect of Mild Hyperglycemia ± Meta-Iodo-Benzylguanidine on the Radiation Response of R3230 Ac Tumors
The effects of glucose or meta-iodo-benzylguanidine (MIBG) on oxygen utilization (QO2) of several tumor cell lines were studied using a Clark-type electrode chamber. For in vivo studies, rats bearing R3230 Ac rat...
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Chapter
Metabolic Effects of Chemotherapy on the Heart
Chemotherapy has led to significant improvement in the management of cancer 1. However, the use of common chemotherapeutic agents is limited by their toxicity to normal tissue 2–5. There are several drugs that...
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Chapter
31P and 13C NMR Studies of Acute and Chronic Adriamycin Cardiotoxicity
Chemotherapy has led to significant improvement in the management of cancer (1). However, the use of most common chemothera-peutic agents is limited by their toxicity to one or more organ systems (2–5) (Table ...
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Article
Solvent exposure of specific nuclei of angiotensin II determined by NMR solvent saturation method
CONFORMATIONAL analysis of peptides in solution by nuclear magnetic resonance (NMR) spectroscopy generally involves determination of the relative exposure to solvent of specific NH hydrogens1–4. The four methods ...
