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Article
Open AccessBlood–brain borders: a proposal to address limitations of historical blood–brain barrier terminology
Many neuroscientists use the term Blood–Brain Barrier (BBB) to emphasize restrictiveness, often equating or reducing the notion of BBB properties to tight junction molecules physically sealing cerebral endothe...
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Article
Open AccessA single mild juvenile TBI in male mice leads to regional brain tissue abnormalities at 12 months of age that correlate with cognitive impairment at the middle age
Traumatic brain injury (TBI) has the highest incidence amongst the pediatric population and its mild severity represents the most frequent cases. Moderate and severe injuries as well as repetitive mild TBI res...
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Article
Open AccessAquaporin 4: a player in cerebral edema and neuroinflammation
Neuroinflammation is a common pathological event observed in many different brain diseases, frequently associated with blood brain barrier (BBB) dysfunction and followed by cerebral edema. Neuroinflammation is...
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Article
Open AccessIncrease of arginase activity in old apolipoprotein-E deficient mice under Western diet associated with changes in neurovascular unit
Aging and atherosclerosis are well-recognized risk factors for cardiac and neurovascular diseases. The Apolipoprotein E deficient (ApoE−/−) mouse on a high-fat diet is a classical model of atherosclerosis, cha...
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Article
Aquaporins in the brain: from aqueduct to “multi-duct”
The aquaporin channel family was first considered as a family of water channels, however it is now clear that some of these channels are also permeable to small solutes such glycerol, urea and monocarboxylates...