5 Result(s)
within
Jeroen S. Dickschat
Chemistry
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Article
Sesquiterpene cyclizations catalysed inside the resorcinarene capsule and application in the short synthesis of isolongifolene and isolongifolenone
Terpenes constitute the largest class of natural products and serve as an important source for medicinal treatments. Despite constant progress in chemical synthesis, the construction of complex polycyclic sesq...
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Article
Catalytic role of carbonyl oxygens and water in selinadiene synthase
Terpene synthases (TSs) catalyse the most complex cyclization cascades in nature, with generation and taming of reactive carbocations. Although deprotonation–reprotonation sequences are frequently relevant for...
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Article
Open AccessOrigin of the 3-methylglutaryl moiety in caprazamycin biosynthesis
Caprazamycins are liponucleoside antibiotics showing bioactivity against Gram-positive bacteria including clinically relevant Mycobacterium tuberculosis by targeting the bacterial MraY-translocase. Their chemical...
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Article
Open AccessIsolation, (bio)synthetic studies and evaluation of antimicrobial properties of drimenol-type sesquiterpenes of Termitomyces fungi
Macrotermitinae termites have farmed fungi in the genus Termitomyces as a food source for millions of years. However, the biochemical mechanisms orchestrating this mutualistic relationship are largely unknown. To...
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Article
Fragmentation and [4 + 3] cycloaddition in sodorifen biosynthesis
Terpenes constitute the largest class of natural products. Their skeletons are formed by terpene cyclases (TCs) from acyclic oligoprenyl diphosphates through sophisticated enzymatic conversions. These enzyme r...
