13 Result(s)
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Jeroen S. Dickschat
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Article
Fragmentation and [4 + 3] cycloaddition in sodorifen biosynthesis
Terpenes constitute the largest class of natural products. Their skeletons are formed by terpene cyclases (TCs) from acyclic oligoprenyl diphosphates through sophisticated enzymatic conversions. These enzyme r...
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Open AccessIsolation, (bio)synthetic studies and evaluation of antimicrobial properties of drimenol-type sesquiterpenes of Termitomyces fungi
Macrotermitinae termites have farmed fungi in the genus Termitomyces as a food source for millions of years. However, the biochemical mechanisms orchestrating this mutualistic relationship are largely unknown. To...
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Open AccessOrigin of the 3-methylglutaryl moiety in caprazamycin biosynthesis
Caprazamycins are liponucleoside antibiotics showing bioactivity against Gram-positive bacteria including clinically relevant Mycobacterium tuberculosis by targeting the bacterial MraY-translocase. Their chemical...
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Open AccessDiscovery of non-squalene triterpenes
All known triterpenes are generated by triterpene synthases (TrTSs) from squalene or oxidosqualene1. This approach is fundamentally different from the biosynthesis of short-chain (C10–C25) terpenes that are forme...
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Catalytic role of carbonyl oxygens and water in selinadiene synthase
Terpene synthases (TSs) catalyse the most complex cyclization cascades in nature, with generation and taming of reactive carbocations. Although deprotonation–reprotonation sequences are frequently relevant for...
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Article
Open AccessTerpene Synthase Genes Originated from Bacteria through Horizontal Gene Transfer Contribute to Terpenoid Diversity in Fungi
Fungi are successful eukaryotes of wide distribution. They are known as rich producers of secondary metabolites, especially terpenoids, which are important for fungi-environment interactions. Horizontal gene t...
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Journal Club
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Open AccessIlluminating the catalytic core of ectoine synthase through structural and biochemical analysis
Ectoine synthase (EctC) is the signature enzyme for the production of ectoine, a compatible solute and chemical chaperone widely synthesized by bacteria as a cellular defense against the detrimental effects of...
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Article
Open AccessDiversity and Functional Evolution of Terpene Synthases in Dictyostelid Social Amoebae
Dictyostelids, or social amoebae, have a unique life style in forming multicellular fruiting bodies from unicellular amoeboids upon starvation. Recently, dictyostelids were found to contain terpene synthase (T...
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Article
Sesquiterpene cyclizations catalysed inside the resorcinarene capsule and application in the short synthesis of isolongifolene and isolongifolenone
Terpenes constitute the largest class of natural products and serve as an important source for medicinal treatments. Despite constant progress in chemical synthesis, the construction of complex polycyclic sesq...
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Article
Genome mining of Streptomyces ambofaciens
Since the discovery of the streptomycin produced by Streptomyces griseus in the middle of the last century, members of this bacterial genus have been largely exploited for the production of secondary metabolites ...
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Microbial production of the drugs violacein and deoxyviolacein: analytical development and strain comparison
Violacein and deoxyviolacein display a broad range of interesting biological properties but their production is rarely distinguished due to the lack of suitable analytical methods. An HPLC method has been deve...
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Article
The Chafer Pheromone Buibuilactone and Ant Pyrazines are also Produced by Marine Bacteria
Headspace extracts obtained from agar plate cultures of two marine bacteria from the North Sea (Germany), Loktanella strain BIO-204 and Dinoroseobacter shibae strain DFL-27, were analyzed by GC-MS. Several γ-lact...
