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Article
Open AccessClinically used broad-spectrum antibiotics compromise inflammatory monocyte-dependent antibacterial defense in the lung
Hospital-acquired pneumonia (HAP) is associated with high mortality and costs, and frequently caused by multidrug-resistant (MDR) bacteria. Although prior antimicrobial therapy is a major risk factor for HAP, ...
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Article
Translating metabolomics into clinical practice
Metabolomics is on the precipice of transforming from a research tool into a powerful clinical platform to improve precision medicine. However, metabolomics methods need to be validated in clinical research to...
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Article
Single cell metabolism: current and future trends
Single cell metabolomics is an emerging and rapidly develo** field that complements developments in single cell analysis by genomics and proteomics. Major goals include map** and quantifying the metabolome...
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Article
Open AccessQuality assurance and quality control reporting in untargeted metabolic phenoty**: mQACC recommendations for analytical quality management
Demonstrating that the data produced in metabolic phenoty** investigations (metabolomics/metabonomics) is of good quality is increasingly seen as a key factor in gaining acceptance for the results of such st...
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Article
Open AccessAnalysis of adherent cell culture lysates with low metabolite concentrations using the Biocrates AbsoluteIDQ p400 HR kit
The AbsoluteIDQ p400 HR kit is a commercial product for targeted metabolomics. While the kit has been validated for human plasma and serum, adherent cell lysates have not yet been evaluated. We have optimized the...
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Article
Open AccessAn integrated host-microbiome response to atrazine exposure mediates toxicity in Drosophila
The gut microbiome produces vitamins, nutrients, and neurotransmitters, and helps to modulate the host immune system—and also plays a major role in the metabolism of many exogenous compounds, including drugs a...
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Article
Open AccessMetabolomics enables precision medicine: “A White Paper, Community Perspective”
Metabolomics is the comprehensive study of the metabolome, the repertoire of biochemicals (or small molecules) present in cells, tissues, and body fluids. The study of metabolism at the global or “-omics” leve...
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Article
Open AccessDirect infusion mass spectrometry metabolomics dataset: a benchmark for data processing and quality control
Direct-infusion mass spectrometry (DIMS) metabolomics is an important approach for characterising molecular responses of organisms to disease, drugs and the environment. Increasingly large-scale metabolomics s...
