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  1. No Access

    Chapter and Conference Paper

    Systemic and Cellular Responses to Intermittent Hypoxia: Evidence for Oxidative Stress and Mitochondrial Dysfunction

    Episodic hypoxia is associated with recurrent apnea syndromes (central or obstructive apneas). Epidemiological studies have shown good correlation between apneas and hypertension, myocardial infarctions and ab...

    Yingjie Peng, Guoxiang Yuan, Jeffrey L. Overholt, Ganesh K. Kumar… in Chemoreception (2003)

  2. No Access

    Chapter

    Chemosensing at the Carotid Body

    Currently, it is notclear what type of K+ channel(s) is active at the resting membrane potential (RMP) in glomus cells of the carotid body (CB). HERO channels produce currents that are known to contribute to the ...

    Jeffrey L. Overholt, Eckhard Ficker, Tianen Yang, Hashim Shams… in Oxygen Sensing (2002)

  3. No Access

    Chapter

    Co2/Hco3 - Modulates K+ and Ca2+ Currents in Glomus Cells of the Carotid Body

    Arterial CO2 and O2 are natural stimuli at the carotid body, the primary peripheral chemoreceptor. CO2 acts synergistically with low oxygen (hypoxia) to stimulate carotid body activity and ultimately ventilation....

    Jeffrey L. Overholt, Beth A. Summers… in Frontiers in Modeling and Control of Breat… (2001)

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    Chapter

    Carbon Monoxide and Carotid Body Chemoreception

    It is being increasingly recognized that endogenously generated carbon monoxide (CO) functions as a chemical messenger in the nervous system. CO is released during the breakdown of heme to biliverdin by the en...

    Jeffrey L. Overholt, Gary R. Bright… in Frontiers in Arterial Chemoreception (1996)

  5. No Access

    Article

    Intracellular ATP and GTP are both required to preserve modulation of N-type calcium channel current by norepinephrine

    Norepinephrine (NE) inhibits voltage-dependent calcium channels of sympathetic neurons. We investigated the role of intracellular nucleotides in this inhibition for clues to receptor-channel coupling mechanism...

    Keith S. Elmslie, Mary Ann Werz, Jeffrey L. Overholt, Stephen W. Jones in Pflügers Archiv (1993)

  6. No Access

    Chapter

    The role of excitatory and inhibitory amino acids in the integration of respiratory and cardiovascular functions

    In order to assess the role of GABA and glutamate in the ventrolateral medulla on vasomotor and respiratory responses, bicuculline (BIC), a GABA receptor antagonist, and kynurenic acid (KYN), a glutamate recep...

    Jyoti Mitra, Jeffrey L. Overholt, Neil S. Cherniack in Amino Acids (1990)