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Article
Open AccessPrevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition
Microbiota-directed complementary food (MDCF) formulations have been designed to repair the gut communities of malnourished children. A randomized controlled trial demonstrated that one formulation, MDCF-2, im...
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Article
Open AccessBioactive glycans in a microbiome-directed food for children with malnutrition
Evidence is accumulating that perturbed postnatal development of the gut microbiome contributes to childhood malnutrition1–4. Here we analyse biospecimens from a randomized, controlled trial of a microbiome-direc...
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Article
Open AccessDevelo** shelf-stable Microbiota Directed Complementary Food (MDCF) prototypes for malnourished children: study protocol for a randomized, single-blinded, clinical study
Childhood undernutrition is a major public health concern that needs special attention to achieve 2025 global nutrition targets. Moderate acute malnutrition (MAM), manifest as wasting (low weight-for-height), ...
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Article
Melding microbiome and nutritional science with early child development
Programs for treating malnutrition in children should consider how food formulations affect postnatal gut microbiome development.
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Article
Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans
Changing food preferences brought about by westernization that have deleterious health effects1,2—combined with myriad forces that are contributing to increased food insecurity—are catalysing efforts to identify ...
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Article
Open AccessProof-of-concept study of the efficacy of a microbiota-directed complementary food formulation (MDCF) for treating moderate acute malnutrition
Childhood undernutrition remains a significant global health challenge accounting for over half of all under 5 child mortality. Moderate acute malnutrition (MAM), which leads to wasting [weight-for-length z-sc...
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Article
Open AccessApplying indirect open-circuit calorimetry to study energy expenditure in gnotobiotic mice harboring different human gut microbial communities
Given the increasing use of gnotobiotic mouse models for deciphering the effects of human microbial communities on host biology, there is a need to develop new methods for characterizing these animals while ma...
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Article
Open AccessStudy of Environmental Enteropathy and Malnutrition (SEEM) in Pakistan: protocols for biopsy based biomarker discovery and validation
Environmental Enteropathy (EE), characterized by alterations in intestinal structure, function, and immune activation, is believed to be an important contributor to childhood undernutrition and its associated ...
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Article
Author Correction: Transposable elements drive widespread expression of oncogenes in human cancers
In the version of this article initially published, grant PF-17-201-01-TBG from the American Cancer Society to author Erica C. Pehrsson was not included in the Acknowledgements. The error has been corrected in...
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Article
Transposable elements drive widespread expression of oncogenes in human cancers
Transposable elements (TEs) are an abundant and rich genetic resource of regulatory sequences1–3. Cryptic regulatory elements within TEs can be epigenetically reactivated in cancer to influence oncogenesis in a p...
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Article
Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist
Both F17-like and type 1 pili promote intestinal colonization in mouse colonic crypts, and the high-affinity mannoside M4284 reduces intestinal colonization of uropathogenic Escherichia coli while simultaneously ...
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Article
A microbial perspective of human developmental biology
When most people think of human development, they tend to consider only human cells and organs. Yet there is another facet that involves human-associated microbial communities. A microbial perspective of human...
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Article
Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice
The relationship between assembly of the gut community and gut mucosal immunoglobulin A responses during the first 24–36 months of postnatal life in a cohort of 40 twin pairs is defined and modelled in gnotobi...
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Article
Genome-wide association study of Arabidopsis thaliana leaf microbial community
Identifying the factors that influence the outcome of host–microbial interactions is critical to protecting biodiversity, minimizing agricultural losses and improving human health. A few genes that determine s...
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Article
Members of the human gut microbiota involved in recovery from Vibrio cholerae infection
Recovery from cholera is characterized by a pattern of accumulation of bacterial taxa that shows similarities to the pattern of maturation of the gut microbiota in healthy children, raising the possibility tha...
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Article
Persistent gut microbiota immaturity in malnourished Bangladeshi children
Bacterial species whose representation defines healthy postnatal assembly of the gut microbiota in Bangladeshi children during their first 2 years are identified, and a model is constructed to compare healthy ...
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Article
The abundance and variety of carbohydrate-active enzymes in the human gut microbiota
The human genome encodes only a small number of digestive glycoside hydrolases for the breakdown of sucrose, lactose and starch. Instead, the large diversity o...
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Article
Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing
A systematic evaluation of parameters that affect short amplicons sequenced on Illumina platforms provides guidelines for how to eliminate erroneous reads and improve data interpretation.
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Article
Diversity, stability and resilience of the human gut microbiota
Trillions of microbes inhabit the human intestine, forming a complex ecological community that influences normal physiology and susceptibility to disease through its collective metabolic activities and host in...
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Article
Going viral: next-generation sequencing applied to phage populations in the human gut
Methods for purifying virus-like particles (VLPs) from microbial communities, procedures for amplifying the small quantities of DNA that are recovered from VLP...
