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Article
Open AccessThrombopoietin receptor agonist antibody for treating chemotherapy-induced thrombocytopenia
Thrombocytopenia is a common complication in cancer patients undergoing chemotherapy. Chemotherapy-induced thrombocytopenia (CIT) leads to dose reduction and treatment delays, lowering chemotherapy efficacy an...
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Article
Open AccessEarly transplantation-related mortality after allogeneic hematopoietic cell transplantation in patients with acute leukemia
Transplantation-related mortality (TRM) is a major obstacle in allogeneic hematopoietic cell transplantation (allo-HCT). Approximately 60–80% of TRM occurs early, within 100 days of transplantation.
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Article
Disruption of the Myc-PDE4B regulatory circuitry impairs B-cell lymphoma survival
A large body of evidence suggests that B-cell lymphomas with enhanced Myc expression are associated with an aggressive phenotype and poor prognosis, which makes Myc a compelling therapeutic target. Phosphodies...
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Article
Open AccessThe non-peptide thrombopoietin receptor agonist eltrombopag stimulates megakaryopoiesis in bone marrow cells from patients with relapsed multiple myeloma
Thrombocytopenia is a significant problem in patients with relapsed or refractory multiple myeloma, precipitating a need for supportive platelet transfusions and necessitating decreases in delivered doses of c...