21 Result(s)

Article

Intra-articular corticosteroid knee injection induces a reduction in meniscal thickness with no treatment effect on cartilage volume: a case–control study

Although intra-articular corticosteroid injections (IACI) are commonly used for the treatment of knee osteoarthritis (OA), there is controversy regarding possible deleterious effects on joint structure. In thi...

Jean-Pierre Pelletier, Jean-Pierre Raynauld, François Abram… in Scientific Reports (2020)

Article

Response to “Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study”

Jean-Pierre Pelletier, Jean-Pierre Raynauld in Arthritis Research & Therapy (2020)

Article

Statin-induced anti-HMGCR myopathy: successful therapeutic strategies for corticosteroid-free remission in 55 patients

To describe successful therapeutic strategies in statin-induced anti-HMGCR myopathy.

Alain Meyer, Yves Troyanov, Julie Drouin… in Arthritis Research & Therapy (2020)

Article

Persistence rates of abatacept and TNF inhibitors used as first or second biologic DMARDs in the treatment of rheumatoid arthritis: 9 years of experience from the Rhumadata® clinical database and registry

Treatment persistence is an important consideration when selecting a therapy for chronic conditions such as rheumatoid arthritis (RA). We assessed the long-term persistence of abatacept or a tumor necrosis fac...

Denis Choquette, Louis Bessette, Evo Alemao, Boulos Haraoui… in Arthritis Research & Therapy (2019)

Article

Impact of oral osteoarthritis therapy usage among other risk factors on knee replacement: a nested case-control study using the Osteoarthritis Initiative cohort

The aim of this study was to measure the association between exposure to commonly used oral osteoarthritis (OA) therapies and relevant confounding risk factors on the occurrence of knee replacement (KR), using...

Marc Dorais, Johanne Martel-Pelletier, Jean-Pierre Raynauld… in Arthritis Research & Therapy (2018)

Article

Exploring determinants predicting response to intra-articular hyaluronic acid treatment in symptomatic knee osteoarthritis: 9-year follow-up data from the Osteoarthritis Initiative

The weight of recommendation for intra-articular therapies such as hyaluronic acid injections varies from one set of guidelines to another, and they have not yet reached unanimity with respect to the usefulnes...

Jean-Pierre Pelletier, Jean-Pierre Raynauld, François Abram… in Arthritis Research & Therapy (2018)

Article

Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study

There is an obvious need to identify biomarkers that could predict patient response to an osteoarthritis (OA) treatment. This post hoc study explored in a 2-year randomized controlled trial in patients with kn...

Johanne Martel-Pelletier, Jean-Pierre Raynauld… in Arthritis Research & Therapy (2017)

Article

Chondroitin sulfate efficacy versus celecoxib on knee osteoarthritis structural changes using magnetic resonance imaging: a 2-year multicentre exploratory study

In osteoarthritis (OA) treatment, although chondroitin sulfate (CS) was found in a number of studies using radiography to have a structure-modifying effect, to date CS use is still under debate. A clinical stu...

Jean-Pierre Pelletier, Jean-Pierre Raynauld… in Arthritis Research & Therapy (2016)

Article

Meniscal extrusion promotes knee osteoarthritis structural progression: protective effect of strontium ranelate treatment in a phase III clinical trial

To evaluate the impact of meniscal extrusion (Ext) on knee osteoarthritis (OA) structural progression and on response to strontium ranelate (SrRan) treatment at 36 months in patients with (+) or without (-) Ex...

Camille Roubille, Johanne Martel-Pelletier… in Arthritis Research & Therapy (2015)

Article

The presence of meniscal lesions is a strong predictor of neuropathic pain in symptomatic knee osteoarthritis: a cross-sectional pilot study

Pain in osteoarthritis (OA) has been classically attributed to joint structural damage. Disparity between the degree of radiographic structural damage and the severity of symptoms implies that factors other th...

Camille Roubille, Jean-Pierre Raynauld, François Abram… in Arthritis Research & Therapy (2014)

Article

Fully automated system for the quantification of human osteoarthritic knee joint effusion volume using magnetic resonance imaging

Joint effusion is frequently associated with osteoarthritis (OA) flare-up and is an important marker of therapeutic response. This study aimed at develo** and validating a fully automated system based on mag...

Wei Li, François Abram, Jean-Pierre Pelletier… in Arthritis Research & Therapy (2010)

Article

Analysis of the precision and sensitivity to change of different approaches to assess cartilage loss by quantitative MRI in a longitudinal multicentre clinical trial in patients with knee osteoarthritis

Cartilage thickness and volume loss measurements using quantitative magnetic resonance imaging (qMRI) are suggested to detect significant cartilage changes over short time intervals. We aimed to compare these ...

Jean-Pierre Raynauld, Johanne Martel-Pelletier… in Arthritis Research & Therapy (2008)

Article

Risk factors associated with the loss of cartilage volume on weight-bearing areas in knee osteoarthritis patients assessed by quantitative magnetic resonance imaging: a longitudinal study

The objective of this study was to identify, on a symptomatic knee osteoarthritis (OA) cohort, the risk factors associated with the progression of the disease. More specifically, we investigated the correlatio...

Jean-Pierre Pelletier, Jean-Pierre Raynauld… in Arthritis Research & Therapy (2007)

Article

Knee meniscal extrusion in a largely non-osteoarthritic cohort: association with greater loss of cartilage volume

We conducted a longitudinal study (duration 2 years), including 294 individuals (mean age 45 years, 58% female), in order to examine associations between meniscal extrusion, knee structure, radiographic change...

Changhai Ding, Johanne Martel-Pelletier… in Arthritis Research & Therapy (2007)

Article

Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow

Osteoarthritis (OA), the most common of all arthritic conditions, is a social and financial burden to all nations. The most recent research has significantly advanced our understanding of the cause of OA and r...

Jean-Pierre Pelletier, Johanne Martel-Pelletier… in Arthritis Research & Therapy (2006)

Article

Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic changes

The objective of this study was to further explore the cartilage volume changes in knee osteoarthritis (OA) over time using quantitative magnetic resonance imaging (qMRI). These were correlated with demographi...

Jean-Pierre Raynauld, Johanne Martel-Pelletier… in Arthritis Research & Therapy (2005)