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  1. Article

    Open Access

    Colon cancer cells adopt an invasive phenotype without mesenchymal transition in 3-D but not 2-D culture upon combined stimulation with EGF and crypt growth factors

    The intestinal crypt homeostasis is maintained by a combination of growth factors including Wnt, R-Spondin1, Noggin and the epidermal growth factor (EGF). In human colorectal cancer, the Wnt pathway is constit...

    Kirsten Ludwig, Edison S Tse, Jean YJ Wang in BMC Cancer (2013)

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  2. No Access

    Article

    Modulation of human checkpoint kinase Chk1 by the regulatory β-subunit of protein kinase CK2

    Protein kinase CK2 is a serine/threonine protein kinase involved in various aspects of cellular regulation. The regulatory β-subunit of CK2 exerts a central role not only in mediating formation of tetrameric CK2 ...

    Barbara Guerra, Olaf-Georg Issinger, Jean YJ Wang in Oncogene (2003)

  3. No Access

    Article

    Regulation of cell death by the Abl tyrosine kinase

    The c-abl proto-oncogene encodes a protein tyrosine kinase that is distributed in the nucleus and the cytoplasm of proliferating cells. In the nucleus, c-Abl activity is negatively regulated by the retinoblastoma...

    Jean YJ Wang in Oncogene (2000)

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    Article

    The SH2-containing adapter protein GRB10 interacts with BCR-ABL

    Bcr-Abl is an oncogenic tyrosine kinase expressed in tumor cells of CML and a subset of ALL which in its unregulated and activated state is thought to cause cell transformation and leukemia. Bcr-Abl contains s...

    Ren Yuan Bai, Thomas Jahn, Sylvia Schrem, Gerd Munzert, K Michael Weidner… in Oncogene (1998)

  5. No Access

    Article

    Hyperphosphorylated p107 and p130 bind to T-antigen: identification of a critical regulatory sequence present in RB but not in p107/p130

    The retinoblastoma tumor suppressor RB and its related proteins, p107 and p130, are targets of several viral oncoproteins, including SV40 large T-antigen (T-Ag) and adenovirus E1A. T-Ag and E1A each contains a...

    Erik S Knudsen, Jean YJ Wang in Oncogene (1998)

  6. No Access

    Article

    Effect of Bcr sequences on the cellular function of the Bcr-Abl oncoprotein

    In Philadelphia chromosome (Ph1)-positive human leukemia, the c-Abl tyrosine kinase is activated by fusion to sequences encoded by the breakpoint cluster region (bcr) gene. Two major types of Bcr-Abl fusion prote...

    John R McWhirter, Jean YJ Wang in Oncogene (1997)

  7. No Access

    Article

    Functional analysis of wild-type and malignant glioma derived CDKN2Aβ alleles: Evidence for an RB-independent growth suppressive pathway

    The tumor suppressor gene CDKN2A (p16/MTS1/INK4A), which encodes the cyclin-dependent kinase inhibitor p16INK4a, is a target of 9p21 deletions during the malignant progression of human gliomas. This gene also enc...

    Wadih Arap, Erik Knudsen, Duane A Sewell, David Sidransky, Jean YJ Wang… in Oncogene (1997)

  8. No Access

    Article

    Point mutations can inactivate in vitro and in vivo activities of p16INK4a/CDKN2A in human glioma

    Deletions of chromosomal region 9p21 are among the most common genetic alterations observed during the clonal evolution of high grade malignant gliomas. Structural and functional evidence has suggested that ho...

    Wadih Arap, Erik S Knudsen, Jean YJ Wang, Webster K Cavenee, H-J Su Huang in Oncogene (1997)