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Article
Modulation of human checkpoint kinase Chk1 by the regulatory β-subunit of protein kinase CK2
Protein kinase CK2 is a serine/threonine protein kinase involved in various aspects of cellular regulation. The regulatory β-subunit of CK2 exerts a central role not only in mediating formation of tetrameric CK2 ...
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Article
Regulation of cell death by the Abl tyrosine kinase
The c-abl proto-oncogene encodes a protein tyrosine kinase that is distributed in the nucleus and the cytoplasm of proliferating cells. In the nucleus, c-Abl activity is negatively regulated by the retinoblastoma...
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Article
The SH2-containing adapter protein GRB10 interacts with BCR-ABL
Bcr-Abl is an oncogenic tyrosine kinase expressed in tumor cells of CML and a subset of ALL which in its unregulated and activated state is thought to cause cell transformation and leukemia. Bcr-Abl contains s...
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Article
Hyperphosphorylated p107 and p130 bind to T-antigen: identification of a critical regulatory sequence present in RB but not in p107/p130
The retinoblastoma tumor suppressor RB and its related proteins, p107 and p130, are targets of several viral oncoproteins, including SV40 large T-antigen (T-Ag) and adenovirus E1A. T-Ag and E1A each contains a...
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Article
Effect of Bcr sequences on the cellular function of the Bcr-Abl oncoprotein
In Philadelphia chromosome (Ph1)-positive human leukemia, the c-Abl tyrosine kinase is activated by fusion to sequences encoded by the breakpoint cluster region (bcr) gene. Two major types of Bcr-Abl fusion prote...
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Article
Functional analysis of wild-type and malignant glioma derived CDKN2Aβ alleles: Evidence for an RB-independent growth suppressive pathway
The tumor suppressor gene CDKN2A (p16/MTS1/INK4A), which encodes the cyclin-dependent kinase inhibitor p16INK4a, is a target of 9p21 deletions during the malignant progression of human gliomas. This gene also enc...
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Article
Point mutations can inactivate in vitro and in vivo activities of p16INK4a/CDKN2A in human glioma
Deletions of chromosomal region 9p21 are among the most common genetic alterations observed during the clonal evolution of high grade malignant gliomas. Structural and functional evidence has suggested that ho...