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  1. No Access

    Article

    Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1

    Conventional dogma presumes that protamine-mediated DNA compaction in sperm is achieved by electrostatic interactions between DNA and the arginine-rich core of protamines. Phylogenetic analysis reveals several...

    Lindsay Moritz, Samantha B. Schon, Mashiat Rabbani… in Nature Structural & Molecular Biology (2023)

  2. No Access

    Article

    Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites

    Meiotic cells invoke breast cancer susceptibility gene 2 (BRCA2) to repair programmed double-stranded DNA breaks and accomplish homologous recombination. The meiosis-specific protein MEILB2 facilitates BRCA2 recr...

    Devon F. Pendlebury, **g**g Zhang… in Nature Structural & Molecular Biology (2021)

  3. No Access

    Article

    Dissecting the telomere–inner nuclear membrane interface formed in meiosis

    Structural and functional analyses of human TRF1 in complex with meiosis-specific protein TERB1 reveal the basis for telomere tethering to the inner nuclear membrane and offer insight into the mechanism of dis...

    Devon F Pendlebury, Yasuhiro Fujiwara… in Nature Structural & Molecular Biology (2017)

  4. No Access

    Article

    Structural basis for nick recognition by a minimal pluripotent DNA ligase

    Chlorella virus DNA ligase, the smallest eukaryotic ligase known, has pluripotent biological activity and an intrinsic nick-sensing function, despite having none of the accessory domains found in cellular liga...

    Pravin A Nair, Jayakrishnan Nandakumar, Paul Smith… in Nature Structural & Molecular Biology (2007)