17 Result(s)
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Open AccessAuthor Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx
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Open AccessThe evolution of lung cancer and impact of subclonal selection in TRACERx
Lung cancer is the leading cause of cancer-associated mortality worldwide1. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer...
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Open AccessAuthor Correction: Comparative and demographic analysis of orang-utan genomes
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Open AccessEscape from nonsense-mediated decay associates with anti-tumor immunogenicity
Frameshift insertion/deletions (fs-indels) are an infrequent but highly immunogenic mutation subtype. Although fs-indels are degraded through the nonsense-mediated decay (NMD) pathway, we hypothesise that some...
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Open AccessConstruction of a high density linkage map in Oil Palm using SPET markers
A high-density genetic linkage map from a controlled cross of two oil palm (Elaeis guineensis) genotypes was constructed based on Single Primer Enrichment Technology (SPET) markers. A 5K panel of hybridization pr...
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Open AccessThe Personal Genome Project-UK, an open access resource of human multi-omics data
Integrative analysis of multi-omics data is a powerful approach for gaining functional insights into biological and medical processes. Conducting these multifaceted analyses on human samples is often complicat...
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Open AccessEnhancer accessibility and CTCF occupancy underlie asymmetric TAD architecture and cell type specific genome topology
Cohesin and CTCF are master regulators of genome topology. How these ubiquitous proteins contribute to cell-type specific genome structure is poorly understood. Here, we explore quantitative aspects of topolog...
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Neoantigen-directed immune escape in lung cancer evolution
The interplay between an evolving cancer and a dynamic immune microenvironment remains unclear. Here we analyse 258 regions from 88 early-stage, untreated non-small-cell lung cancers using RNA sequencing and h...
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Correction: Corrigendum: Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
Nature 545, 446–451 (2017); doi:10.1038/nature22364 For 6 of the 96 patients included in this Article (patients CRUK0014, CRUK0030, CRUK0048, CRUK0059, CRUK0096 and CRUK0097) incorrect tumour volumetric data a...
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Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for l...
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Open AccessA comparative encyclopedia of DNA elements in the mouse genome
The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To gain greater in...
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Open AccessGibbon genome and the fast karyotype evolution of small apes
Gibbons are small arboreal apes that display an accelerated rate of evolutionary chromosomal rearrangement and occupy a key node in the primate phylogeny between Old World monkeys and great apes. Here we prese...
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Correction: Corrigendum: The zebrafish reference genome sequence and its relationship to the human genome
Nature 496, 498–503 (2013); doi:10.1038/nature12111 In this Letter, five authors were inadvertently omitted: Sharmin Begum and Christine Lloyd from the Wellcome Trust Sanger Institute, and Christa Lanz, Günter...
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Open AccessThe zebrafish reference genome sequence and its relationship to the human genome
A high-quality sequence assembly of the zebrafish genome reveals the largest gene set of any vertebrate and provides information on key genomic features, and comparison to the human reference genome shows that...
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Open AccessInsights into hominid evolution from the gorilla genome sequence
Gorillas are humans’ closest living relatives after chimpanzees, and are of comparable importance for the study of human origins and evolution. Here we present the assembly and analysis of a genome sequence fo...
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Open AccessA high-resolution map of human evolutionary constraint using 29 mammals
The comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes. We confirm that at least 5.5% of the ...
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Open AccessComparative and demographic analysis of orang-utan genomes
The genome of the Southeast Asian great ape or orang-utan has been sequenced — specifically a draft assembly of a Sumatran female individual and short-read sequence data from five further Sumatran and five Bor...
