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Chapter
Defining Multiple Myeloma as a Target for DNA Vaccines
New therapies in multiple myeloma (MM) now achieve disease remission in the majority of cases and open the possibility of immunotherapeutic intervention during the stage of minimal residual disease. Active vac...
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Protocol
A DNA Vaccine Strategy for Effective Antibody Induction to Pathogen-Derived Antigens
DNA-based vaccines are currently being developed for treating a diversity of human diseases including cancers, autoimmune conditions, allergies, and microbial infections. In this chapter, we present a general ...
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Article
Open AccessThe L1-type cell adhesion molecule Neuroglian is necessary for maintenance of sensory axon advance in the Drosophila embryo
Cell adhesion molecules have long been implicated in the regulation of axon growth, but the precise cellular roles played by individual cell adhesion molecules and the molecular basis for their action are stil...
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Article
DNA vaccines: precision tools for activating effective immunity against cancer
Preventative vaccination against infectious organisms has had a dramatic effect on public health. Therapeutic vaccination against cancer is more challenging bu...
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Article
New strategies for vaccination and imunomodulation in NHL
Knowledge of the genetic changes which occur in cancer cells is stimulating research aimed towards new therapies. Immunotherapeutic approaches, particularly antibody therapy, are already finding a place in tr...
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Protocol
DNA Fusion Vaccines Against B-Cell Tumors
The ability of naked DNA to induce immune responses against encoded antigen has been clearly demonstrated for infectious diseases (1). In many cases, the induced immunity is able to protect against infection, and...
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Article
DNA vaccines with single-chain Fv fused to fragment C of tetanus toxin induce protective immunity against lymphoma and myeloma
Vaccination with idiotypic protein protects against B-cell lymphoma, mainly through anti-idiotypic antibody. For use in patients, DNA vaccines containing single-chain Fv derived from tumor provid...
