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Article
Discovery of circulating blood biomarkers in patients with and without Modic changes of the lumbar spine: a preliminary analysis
The following study aimed to determine the existence of blood biomarkers in symptomatic patients with or without lumbar Modic changes (MC).
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Article
Open AccessAssociation between vertebral cross-sectional area and lumbar disc displacement – a population-based study
Vertebral dimensions may constitute a potential risk factor for degenerative changes in the spine. Previous studies have found a positive association between vertebral height and both type 2 Modic changes and ...
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Article
Open AccessA prognostic risk score for development and spread of chronic pain
Chronic pain is a complex condition influenced by a combination of biological, psychological and social factors. Using data from the UK Biobank (n = 493,211), we showed that pain spreads from proximal to distal s...
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Article
Open AccessEarly disc degeneration in radiotherapy-treated childhood brain tumor survivors
Childhood brain tumor (BT) survivors have an increased risk of treatment-related late effects, which can reduce health-related quality of life and increase morbidity. This study aimed to investigate lumbar dis...
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Article
Open AccessAssociation of accelerometer-measured physical activity, back static muscular endurance and abdominal obesity with radicular pain and non-specific low back pain
Low back pain (LBP) is the leading cause of disability worldwide and often associated with lifestyle factors. However, studies further examining the role of these lifestyle factors in non-specific low back pai...
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Article
Open AccessThe role of co-occurring insomnia and mental distress in the association between lumbar disc degeneration and low back pain related disability
Lumbar disc degeneration (LDD) is associated with low back pain (LBP). Although both insomnia and mental distress appear to influence the pain experience, their role in the association between LDD and LBP is u...
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Article
Open AccessFamily structure and multisite musculoskeletal pain in adolescence: a Northern Finland Birth Cohort 1986 study
Family structure is suggested to be associated with adolescent pain, but evidence on its association with multisite MS pain is sparse. The purpose of this cross-sectional study was to investigate the potential...
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Article
Open AccessParticipatory Ergonomics Intervention to Prevent Work Disability Among Workers with Low Back Pain: A Randomized Clinical Trial in Workplace Setting
Purpose In order to support people with low back pain (LBP) to stay at work, work arrangements are regarded important. This study aimed to evaluate the effectiveness of a workplace intervention using a participat...
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Article
Learning-based fully automated prediction of lumbar disc degeneration progression with specified clinical parameters and preliminary validation
Lumbar disc degeneration (LDD) may be related to aging, biomechanical and genetic factors. Despite the extensive work on understanding its etiology, there is currently no automated tool for accurate prediction...
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Article
Open AccessAssociation of lumbar disc degeneration with low back pain in middle age in the Northern Finland Birth Cohort 1966
Although it has been suggested that lumbar disc degeneration (LDD) is a significant risk factor for low back pain (LBP), its role remains uncertain. Our objective was to clarify the association between LDD and...
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Article
Integrative analysis of metabolomic, genomic, and imaging-based phenotypes identify very-low-density lipoprotein as a potential risk factor for lumbar Modic changes
Modic changes (MC) on magnetic resonance imaging (MRI) have been associated with the development and severity of low back pain (LBP). The etiology of MC remains elusive, but it has been suggested that altered ...
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Article
Open AccessPain fingerprinting using multimodal sensing: pilot study
Pain is a complex phenomenon, the experience of which varies widely across individuals. At worst, chronic pain can lead to anxiety and depression. Cost-effective strategies are urgently needed to improve the t...
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Article
A new immunometabolic perspective of intervertebral disc degeneration
Intervertebral disc (IVD) degeneration is a common finding on spine imaging that increases in prevalence with age. IVD degeneration is a frequent cause of low back pain, which is a leading cause of disability....
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Article
Open AccessPatient education booklet to support evidence-based low back pain care in primary care – a cluster randomized controlled trial
Inappropriate imaging and low-value care for low back pain (LBP) are common. A new patient-education booklet was created to overcome identified barriers to the delivery of recommended care, including the use o...
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Article
Open AccessWork-related risk factors for ulnar nerve entrapment in the Northern Finland Birth Cohort of 1966
Ulnar nerve entrapment (UNE) is the second most common entrapment neuropathy in the upper extremity. The aetiology of UNE is multifactorial and is still not fully understood. The aim of the study was to identi...
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Article
Serum biomarkers for Modic changes in patients with chronic low back pain
Lumbar Modic change (MC) can serve as a diagnostic marker as well as an independent source of chronic low back pain (CLBP). This study aimed to test for the existence of serum biomarkers in CLBP patients with MC.
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Article
Open AccessAssociation between device-measured physical activity and lumbar Modic changes
Modic changes (MC) in the lumbar spine are considered one potential etiological factor behind low back pain (LBP). Multiple risk factors for MC have been suggested, including male gender, smoking and factors a...
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Article
Open AccessAccumulated unhealthy behaviors and psychosocial problems in adolescence are associated with labor market exclusion in early adulthood – a northern Finland birth cohort 1986 study
The relevance of health-related behaviors to exclusion from the labor market in early adulthood remains poorly studied in relation to the magnitude of the problem. We explored whether adolescents’ accumulated ...
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Article
Open AccessTemporal Trends in Vertebral Dimensions – a case study from Finland
Vertebral fractures and other back problems represent a major, increasing worldwide health problem. This has increased the need to better understand the reasons behind this phenomenon. In addition to a reducti...
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Article
Open AccessAssociation of STarT Back Tool and the short form of the Örebro Musculoskeletal Pain Screening Questionnaire with multidimensional risk factors
The Short form of the Örebro Musculoskeletal Pain Screening Questionnaire (ÖMPSQ-short) and the STarT Back Tool (SBT) have been developed to screen for risk factors for future low back pain (LBP) -related disa...
