13 Result(s)
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Janitza L Montalvo-Ortiz
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Article
Correction: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge
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Article
Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge
GrimAge acceleration has previously predicted age-related morbidities and mortality. In the current study, we sought to examine how GrimAge is associated with genetic predisposition for systemic inflammation a...
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Article
Open AccessProfiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex
Opioid use disorder (OUD) is influenced by genetic and environmental factors. While recent research suggests epigenetic disturbances in OUD, this is mostly limited to DNA methylation (5mC). DNA hydroxymethylat...
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Article
Cross-ancestry genomic research: time to close the gap
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Article
Open AccessEpigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veterans
Posttraumatic stress disorder (PTSD) is a chronic and disabling psychiatric disorder prevalent in military veterans. Epigenetic mechanisms have been implicated in the etiology of PTSD, with DNA methylation bei...
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Article
Open AccessDNA methylation changes in African American women with a history of preterm birth from the InterGEN study
Preterm birth (< 37 weeks’ gestation) is a common outcome of pregnancy that has been associated with increased risk of cardiovascular disease for women later in life. Little is known about the physiologic mech...
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The Role of 5-HT2B Receptor on Aggression and Drugs of Abuse
Monoamines, particularly serotonin (5-hydroxytryptamine, 5-HT), have been extensively studied in the context of aggression. 5-HT is known to play a key role in the modulation of aggressive, impulsive, antisoci...
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Article
Open AccessAuthor Correction: Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessGenomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women
There is currently an epidemic of opioid use, overdose, and dependence in the United States. Although opioid dependence (OD) is more prevalent in men, opioid relapse and fatal opioid overdoses have recently in...
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Article
Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response
Cannabis use is increasing in the United States, as are its adverse effects. We investigated the genetics of an adverse consequence of cannabis use: cannabis-related aggression (CRA) using a genome-wide associ...
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Article
Methylation in OTX2 and related genes, maltreatment, and depression in children
Through unbiased transcriptomics and multiple molecular tools, transient downregulation of the Orthodenticle homeobox 2 (OTX2) gene was recently causatively associated with the development of depressive-like beha...
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Article
Histone deacetylase inhibitors reverse age-related increases in side effects of haloperidol in mice
Older patients can be especially susceptible to antipsychotic-induced side effects, and the pharmacodynamic mechanism underlying this phenomenon remains unclear. We hypothesized that age-related epigenetic alt...
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Article
HDAC Inhibitors Restore the Capacity of Aged Mice to Respond to Haloperidol through Modulation of Histone Acetylation
Antipsychotic drugs are widely prescribed to elderly patients for the treatment of a variety of psychopathological conditions, including psychosis and the behavioral disturbances associated with dementia. Howe...
