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Article
Open AccessSubstrate-induced condensation activates plant TIR domain proteins
Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors with an N-terminal Toll/interleukin-1 receptor (TIR) domain mediate recognition of strain-specific pathogen effectors, typically via their C-...
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Article
Open AccessThe receptor kinase SRF3 coordinates iron-level and flagellin dependent defense and growth responses in plants
Iron is critical for host–pathogen interactions. While pathogens seek to scavenge iron to spread, the host aims at decreasing iron availability to reduce pathogen virulence. Thus, iron sensing and homeostasis ...
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Article
The EDS1–PAD4–ADR1 node mediates Arabidopsis pattern-triggered immunity
Plants deploy cell-surface and intracellular leucine rich-repeat domain (LRR) immune receptors to detect pathogens1. LRR receptor kinases and LRR receptor proteins at the plasma membrane recognize microorganism-d...
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Article
Open AccessPathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity
Plants utilise intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors to detect pathogen effectors and activate local and systemic defence. NRG1 and ADR1 “helper” NLRs (RNLs) cooperate wi...
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Article
Genetic strategies for improving crop yields
The current trajectory for crop yields is insufficient to nourish the world’s population by 20501. Greater and more consistent crop production must be achieved against a backdrop of climatic stress that limits yi...
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Article
Open AccessAn EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis
Plant intracellular NLR receptors recognise pathogen interference to trigger immunity but how NLRs signal is not known. Enhanced disease susceptibility1 (EDS1) heterodimers are recruited by Toll-interleukin1-r...
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Article
NLR locus-mediated trade-off between abiotic and biotic stress adaptation in Arabidopsis
Osmotic stress caused by drought, salt or cold decreases plant fitness. Acquired stress tolerance defines the ability of plants to withstand stress following an initial exposure1. We found previously that acquire...
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Article
Open AccessA glimpse into the future of genome-enabled plant biology from the shores of Cold Spring Harbor
A report on the 10th plant genome meeting entitled ‘Plant genomes and biotechnology: from genes to networks’, held at Cold Spring Harbor Laboratory, 2–5 December, 2015.
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Article
Natural variation at Strubbelig Receptor Kinase 3 drives immune-triggered incompatibilities between Arabidopsis thaliana accessions
Matthieu Reymond and colleagues show that natural genetic variants at the SRF3 locus underlie genetic incompatibilities between European and central Asian accessions of Arabidopsis.
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Chapter
Myelodysplasia-Related AML
The myelodysplastic syndromes (MDSs) comprise a heterogeneous group of clonal stem cell disorders characterized by ineffective hematopoiesis (1). Because progression to acute myeloid leukemia (AML) occurs in one-...
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Article
Plant Immunity: A Complex Interface between Host and Pathogen
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Article
The Role of Apoptosis in the Pathogenesis of the Myelodysplastic Syndromes
The paradoxical occurrence of peripheral cytopenias despite a normo/hypercellular marrow in myelodysplastic syndromes (MDS) has been attributed to excessive intramedullary hematopoietic cell apoptosis. It has ...
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Article
Different cell-wall components from Phytophthora megasperma f. sp. glycinea elicit phytoalexin production in soybean and parsley
Different components of a crude cell-wall preparation from the phytopathogenic fungus, Phytophthora megasperma f. sp. glycinea, act as elicitors of phytoalexin accumulation in parsley (Petroselinum crispum) and s...
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Citrate Synthase Messenger RNA in Relation to Enzyme Synthesis in Euglena
The unicellular biflagellate Euglena gracilis is unusual amoungst eukaryotes in being able to thrive both as a phototroph in the light and as an organotroph in the dark, and rapidly adjusts its cellular machinery...
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Interpretation of Antimalarial Activity in Terms of Regression Analyses, Molecular Orbital Calculations, and Theory of DNA-Drug Binding
In 1965 a model to account for the antimalarial activity of chloroquine and its congeners was proposed by O’Brien and Hahn (O’Brien and Hahn, 1965) (see Fig. 1).
