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Article
Open AccessMolecular species of oxidized phospholipids in brain differentiate between learning- and memory impaired and unimpaired aged rats
Loss of cognitive function is a typical consequence of aging in humans and rodents. The extent of decline in spatial memory performance of rats, assessed by a hole-board test, reaches from unimpaired and compa...
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Article
Open AccessCognitive profiling and proteomic analysis of the modafinil analogue S-CE-123 in experienced aged rats
The lack of novel cognitive enhancer drugs in the clinic highlights the prediction problems of animal assays. The objective of the current study was to test a putative cognitive enhancer in a rodent cognitive ...
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Article
Reinstatement of synaptic plasticity in the aging brain through specific dopamine transporter inhibition
Aging-related neurological deficits negatively impact mental health, productivity, and social interactions leading to a pronounced socioeconomic burden. Since declining brain dopamine signaling during aging is...
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Article
Doublecortin and IGF-1R protein levels are reduced in spite of unchanged DNA methylation in the hippocampus of aged rats
The aim of the current study was to investigate whether doublecortin (DCX), insulin-like growth factor receptor 1 (IGF-1R) and metabotropic glutamate receptor 5 (mGluR5) levels are indeed modified in the aging...
