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  1. No Access

    Article

    Identification of early neurodegenerative pathways in progressive multiple sclerosis

    Progressive multiple sclerosis (MS) is characterized by unrelenting neurodegeneration, which causes cumulative disability and is refractory to current treatments. Drug development to prevent disease progressio...

    Max Kaufmann, Anna-Lena Schaupp, Rosa Sun, Fabian Coscia… in Nature Neuroscience (2022)

  2. No Access

    Article

    Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate

    The oncometabolite (R)-2-hydroxyglutarate (R-2-HG) produced by isocitrate dehydrogenase (IDH) mutations promotes gliomagenesis via DNA and histone methylation. Here, we identify an additional activity of R-2-HG: ...

    Lukas Bunse, Stefan Pusch, Theresa Bunse, Felix Sahm, Khwab Sanghvi… in Nature Medicine (2018)