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  1. Article

    Open Access

    Low-cost and clinically applicable copy number profiling using repeat DNA

    Somatic copy number alterations (SCNAs) are an important class of genomic alteration in cancer. They are frequently observed in cancer samples, with studies showing that, on average, SCNAs affect 34% of a canc...

    Sam Abujudeh, Sebastian S. Zeki, Meta C.J. van Lanschot, Mark Pusung… in BMC Genomics (2022)

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  2. Article

    Open Access

    Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas

    Oesophageal adenocarcinoma (OAC) provides an ideal case study to characterize large-scale rearrangements. Using whole genome short-read sequencing of 383 cases, for which 214 had matched whole transcriptomes, ...

    Alvin Wei Tian Ng, Gianmarco Contino, Sarah Killcoyne… in Communications Biology (2022)

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  3. No Access

    Article

    The Role of Continuing Perioperative Chemotherapy Post Surgery in Patients with Esophageal or Gastroesophageal Junction Adenocarcinoma: a Multicenter Cohort Study

    The aim of this cohort study was to assess the benefit that patients with lower esophageal or gastroesophageal junction (E/GEJ) adenocarcinoma receive by continuing perioperative chemotherapy post-surgery.

    George Papaxoinis, Konstantinos Kamposioras… in Journal of Gastrointestinal Surgery (2019)

  4. No Access

    Article

    Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma

    Rebecca Fitzgerald and colleagues report whole-genome sequence analyses of 23 paired samples of Barrett's esophagus and esophageal adenocarcinoma. Their analyses of the clonal architecture of these lesions sho...

    Caryn S Ross-Innes, Jennifer Becq, Andrew Warren, R Keira Cheetham… in Nature Genetics (2015)

  5. Article

    Open Access

    Mobile element insertions are frequent in oesophageal adenocarcinomas and can mislead paired-end sequencing analysis

    Mobile elements are active in the human genome, both in the germline and cancers, where they can mutate driver genes.

    Anna L. Paterson, Jamie M.J. Weaver, Matthew D. Eldridge, Simon Tavaré… in BMC Genomics (2015)

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  6. No Access

    Article

    Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis

    Rebecca Fitzgerald and colleagues used genome sequence analyses to study the progression from premalignant Barrett's esophagus to esophageal adenocarcinoma (EAC) and found that the majority of recurrently muta...

    Jamie M J Weaver, Caryn S Ross-Innes, Nicholas Shannon, Andy G Lynch… in Nature Genetics (2014)

  7. No Access

    Article

    The '–omics' revolution and oesophageal adenocarcinoma

  8. The majority of patients with oesophageal adenocarcinoma (OAC) undergoing surgery with curative intent will relapse and eventually succumb to their disease

    ...

    9. Jamie M. J. Weaver, Caryn S. Ross-Innes… in Nature Reviews Gastroenterology & Hepatolo… (2014)