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Open AccessAptameric hirudins as selective and reversible EXosite-ACTive site (EXACT) inhibitors
Potent and selective inhibition of the structurally homologous proteases of coagulation poses challenges for drug development. Hematophagous organisms frequently accomplish this by fashioning peptide inhibitor...
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Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass
An aptamer is combined with a drug to prevent clot formation in a model of cardiopulmonary bypass.
