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Article
Open AccessA randomised controlled trial of Standard Of Care versus RadioAblaTion in Early Stage HepatoCellular Carcinoma (SOCRATES HCC)
Therapeutic options for early-stage hepatocellular carcinoma (HCC) in individual patients can be limited by tumor and location, liver dysfunction and comorbidities. Many patients with early-stage HCC do not re...
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Article
Open AccessHigh prevalence of diabetes among young First Nations Peoples with metabolic dysfunction-associated steatotic liver disease: a population-based study in Australia
Liver disease is an important contributor to the mortality gap between First Nations Peoples and non-Indigenous Australian adults. Despite a high burden of metabolic comorbidities among First Nations Peoples, ...
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Article
Open AccessA discrete choice experiment to elicit preferences for a liver screening programme in Queensland, Australia: a mixed methods study to select attributes and levels
In Australia, the overall prevalence of liver disease is increasing. Maximising uptake of community screening programmes by understanding patient preferences is integral to develo** consumer-centred care mod...
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Article
Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography
We aimed to validate newly proposed noninvasive criteria for diagnosing clinically significant portal hypertension (CSPH) using liver stiffness measurements (LSM) by transient elastography (TE) and platelet co...
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Article
Open AccessImplementing the right care in the right place at the right time for non-alcoholic fatty liver disease (NAFLD-RRR study): a study protocol for a community care pathway for people with type 2 diabetes
Non-alcoholic fatty liver disease (NAFLD) is an emerging epidemic that affects approximately half of all people with type 2 diabetes. Those with type 2 diabetes are a high-risk NAFLD subgroup because of their ...
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Article
Open AccessThe fate of indeterminate liver lesions: What proportion are precursors of hepatocellular carcinoma?
The natural history and incidence of hepatocellular carcinoma (HCC) arising from indeterminate liver lesions are not well described. We aimed to define the incidence of HCC in a cohort of patients undergoing s...
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Chapter
Liver Transplantation
Liver transplantation (LT) has evolved from a semi-experimental procedure in the 1960s to become a routine intervention with excellent results in patients with both acute and chronic liver diseases. Improvemen...
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Article
Transjugular Intrahepatic Portosystemic Shunts for Hepatorenal Syndrome: TIP** the Scales in Whose Favor?
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Article
Liver Transplantation for Alcoholic Liver Disease: Absence of Evidence for the Relevance of Abstinence
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Article
Open AccessProtocol for a randomised trial testing a community fibrosis assessment service for patients with suspected non-alcoholic fatty liver disease: LOCal assessment and triage evaluation of non-alcoholic fatty liver disease (LOCATE-NAFLD)
Non-alcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease in Australia and its recent increase mirrors the obesity and type 2 diabetes epidemics. Currently, many patients who p...
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Article
Readmission Following Hospitalization for Alcoholic Hepatitis: Costly or Cost-Effective?
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Article
Open AccessCost-comparison analysis of FIB-4, ELF and fibroscan in community pathways for non-alcoholic fatty liver disease
The identification of patients with advanced liver fibrosis secondary to non-alcoholic fatty liver disease (NAFLD) remains challenging. Using non-invasive liver fibrosis tests (NILT) in primary care may permit...
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Article
Open AccessLong-term impact of liver function on curative therapy for hepatocellular carcinoma: application of the ALBI grade
Application of curative therapy for hepatocellular carcinoma is crucially dependent on underlying liver function. Using the recently described ALBI grade we examined the long-term impact of liver dysfunction o...
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Chapter and Conference Paper
Consensus Statements: Management of the Acute Bleeding Episode
Six-week mortality should be the primary end point for studies for treatment of acute variceal bleeding (5;D).
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Chapter and Conference Paper
A la Carte Treatment of Acute Variceal Bleeding
Failure to control bleeding remains challenging to define, despite many attempts of the community of experts. Even if it is associated with survival, regulatory agencies do not consider this endpoint as a reli...
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Article
Open AccessThe accuracy of respiratory rate assessment by doctors in a London teaching hospital: a cross-sectional study
Respiratory rate (RR) is one of the most sensitive markers of a patient condition and a core aspect of multiple clinical assessment tools. Doctors use a number of methods to assess RR, including formal measure...
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Article
Open AccessNeurogenic diabetes insipidus presenting in a patient with subacute liver failure: a case report
To the best of our knowledge, this is the first report in the literature of development of neurogenic diabetes insipidus in a patient with subacute liver failure.
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Article
Open AccessGeneration of functional CD8+ T Cells by human dendritic cells expressing glypican-3 epitopes
Glypican 3 (GPC-3) is an oncofoetal protein that is expressed in most hepatocellular carcinomas (HCC). Since it is a potential target for T cell immunotherapy, we investigated the generation of functional, GPC...
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Article
Predictors of early rebleeding and mortality after acute variceal hemorrhage in patients with cirrhosis
Despite improvements over the past 20 years in patient survival following episodes of acute variceal hemorrhage (AVH) secondary to cirrhosis, AVH is still associated with a high rate of mortality. The ability ...
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Article
Observations on the nature and treatment of dropsy, particularly of hydrothorax and anasarca, with cases
