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Article
Small molecule antagonists of the TGF-β1/TGF-β receptor binding interaction
Excessive and inappropriate action of transforming growth factor (TGF)-β has been implicated in the pathogenesis of several disease processes, especially cancer and fibrosis. To identify antagonists of the TGF...
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Article
Transforming growth factor-β and multidrug resistance in chronic lymphocytic leukemia
Patients with chronic lymphocytic leukemia (CLL) frequently respond to initial treatment, but then become resistant to chemotherapy. Studies have shown one important cause of chemotherapeutic resistance to be ...