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  1. Article

    Open Access

    Pathway analysis of genome-wide data improves warfarin dose prediction

    Many genome-wide association studies focus on associating single loci with target phenotypes. However, in the setting of rare variation, accumulating sufficient samples to assess these associations can be diff...

    Roxana Daneshjou, Nicholas P Tatonetti, Konrad J Karczewski, Hersh Sagreiya… in BMC Genomics (2013)

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  2. No Access

    Article

    Alcohol, genetics and risk of breast cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial

    We tested the hypothesis that genes involved in the alcohol oxidation pathway modify the association between alcohol intake and breast cancer. Subjects were women aged 55–74 at baseline from the screening arm ...

    Catherine A. McCarty, Douglas J. Reding… in Breast Cancer Research and Treatment (2012)

  3. No Access

    Article

    Understanding the pharmacogenetic approach to warfarin dosing

    Warfarin remains the drug of choice for long-term anticoagulation management in a variety of conditions. Despite an established role in prevention of thromboembolic events such as stroke, warfarin continues to...

    Ingrid Glurich, James K. Burmester, Michael D. Caldwell in Heart Failure Reviews (2010)

  4. No Access

    Protocol

    DMET™ Microarray Technology for Pharmacogenomics-Based Personalized Medicine

    Human genome sequence variation in the form of single nucleotide polymorphisms (SNPs) as well as more complex structural variation such as insertions, duplications, and deletions underlies each individual’s re...

    James K. Burmester, Marina Sedova… in Microarray Methods for Drug Discovery (2010)

  5. Article

    Open Access

    Lack of evidence of WNT3A as a candidate gene for congenital vertebral malformations

    Prior investigations have not identified a major locus for vertebral malformations, providing evidence that there is genetic heterogeneity for this condition. WNT3A has recently been identified as a negative regu...

    Nader Ghebranious, Cathleen L Raggio, Robert D Blank, Elizabeth McPherson… in Scoliosis (2007)

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  6. No Access

    Article

    Small molecule antagonists of the TGF-β1/TGF-β receptor binding interaction

    Excessive and inappropriate action of transforming growth factor (TGF)-β has been implicated in the pathogenesis of several disease processes, especially cancer and fibrosis. To identify antagonists of the TGF...

    James K. Burmester, Sherry A. Salzman, Kai Qi Zhang, Richard A. Dart in Medical Oncology (2006)

  7. No Access

    Article

    Transforming growth factor-β and multidrug resistance in chronic lymphocytic leukemia

    Patients with chronic lymphocytic leukemia (CLL) frequently respond to initial treatment, but then become resistant to chemotherapy. Studies have shown one important cause of chemotherapeutic resistance to be ...

    William R Friedenberg, Sherry A Salzman, Sonja M Phan… in Medical Oncology (1999)