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Article
Open AccessA new peucemycin derivative and impacts of peuR and bldA on peucemycin biosynthesis in Streptomyces peucetius
Streptomyces peucetius ATCC 27952 is known to produce a variety of secondary metabolites, including two important antitumor anthracyclines: daunorubicin and doxorubicin. Identification of peucemycin and 25-hydrox...
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Article
Biosynthetic pathway of peucemycin and identification of its derivative from Streptomyces peucetius
Streptomyces peucetius ATCC 27952 is a well-known producer of important anticancer compounds, daunorubicin and doxorubicin. In this study, we successfully identified a new macrolide, 25-hydroxy peucemycin, that e...
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Article
Genome mining Streptomyces sp. KCTC 0041BP as a producer of dihydrochalcomycin
Streptomyces sp. KCTC 0041BP, which was isolated from a soil sample in Cheolwon, Republic of Korea, is a dihydrochalcomycin producer. In this study, we obtained the genome of S. sp. KCTC 0041BP with 7.54 Mb genom...
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Article
Open AccessAuthor Correction: Genome-enabled discovery of anthraquinone biosynthesis in Senna tora
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21987-7
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Article
The genome insights of Streptomyces lannensis T1317-0309 reveals actinomycin D production
The members of Streptomyces have been identified as a major source of antimicrobial agents with broad spectrum. This study is mainly focused on bioactivity-guided isolation and characterization of bioactive molec...
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Article
Open AccessGenome-enabled discovery of anthraquinone biosynthesis in Senna tora
Senna tora is a widely used medicinal plant. Its health benefits have been attributed to the large quantity of anthraquinones, but how they are made in plants remains a mystery. To identify the genes responsible ...
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Article
Regio-specific biotransformation of alizarin to alizarin methoxide with enhanced cytotoxicity against proliferative cells
Alizarin has been reported to have an antigenotoxic activity along with an inhibitory effect on the tumor cell growth of human colon carcinoma cells. Alizarin was biotransformed into an O-methoxide derivative usi...
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Article
Functional Characterization of NgnL, an Alpha/beta-hydrolase Enzyme Involved in Biosynthesis of Acetylated Nodusmicin
Nodusmicin and 18-O-acetyl-nodusmicin were isolated as a co-metabolite of nargenicin from Nocardia sp. CS682. NgnL belonging to the α/β-hydrolase superfamily was heterologously expressed in Escherichia coli BL21 ...
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Article
Open AccessStreptomyces sp. VN1, a producer of diverse metabolites including non-natural furan-type anticancer compound
Streptomyces sp. VN1 was isolated from the coastal region of Phu Yen Province (central Viet Nam). Morphological, physiological, and whole genome phylogenetic analyses suggested that strain Streptomyces sp. VN1 be...
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Article
Increased Production of Dicinnamoylmethane Via Improving Cellular Malonyl-CoA Level by Using a CRISPRi in Escherichia coli
Curcuminoids are natural phenylpropanoids that are biosynthesized via an L-phenylalanine metabolism pathway in turmeric (Curcuma longa L.). Curcuminoids have various chemopreventive activities and pharmaceutical ...
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Article
Exploration of cryptic organic photosensitive compound as Zincphyrin IV in Streptomyces venezuelae ATCC 15439
Zincphyrin IV is a potential organic photosensitizer which is of significant interest for applications in biomedicine, materials science, agriculture (as insecticide), and chemistry. Most studies on Zincphyrin...
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Article
Open AccessPublisher Correction: The effect of introducing antibiotics into organic light-emitting diodes
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessThe effect of introducing antibiotics into organic light-emitting diodes
The quest to improve the performance of organic light-emitting diodes (OLEDs) has led to the exploration of new materials with properties like interfacial dipole, excitons generation, and bandgap alignment. He...
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Article
Correction to: Cascade biocatalysis systems for bioactive naringenin glucosides and quercetin rhamnoside production from sucrose
The name of the author “Yamaguchi Tokutaro” is incorrect for the first and last name has been interchanged. The correct presentation is “Tokutaro Yamaguchi”.
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Article
Cascade biocatalysis systems for bioactive naringenin glucosides and quercetin rhamnoside production from sucrose
Two sustainable and cost-effective cascade enzymatic systems were developed to regenerate uridine diphosphate (UDP)-α-d-glucose and UDP-β-l-rhamnose from sucrose. The systems were coupled with the UDP generating ...
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Article
Open AccessAuthor Correction: Overcoming NADPH product inhibition improves D-sorbitol conversion to L-sorbose
An amendment to this paper has been published and can be accessed via a link at the top of the paper
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Article
Open AccessEngineering actinomycetes for biosynthesis of macrolactone polyketides
Actinobacteria are characterized as the most prominent producer of natural products (NPs) with pharmaceutical importance. The production of NPs from these actinobacteria is associated with particular biosynthe...
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Article
Biosynthesis of resveratrol and piceatannol in engineered microbial strains: achievements and perspectives
Resveratrol (3,5,4′-trihydroxystilbene) and piceatannol (3,5,3′,4′-tetrahydroxystilbene) are well-known natural products that are produced by plants. They are important ingredients in pharmaceutical industries...
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Article
Bioactive molecules from Nocardia: diversity, bioactivities and biosynthesis
Nocardia spp. are catalase positive, aerobic, and non-motile Gram-positive filamentous bacteria. Many Nocarida spp. have been reported as unusual causes of diverse clinical diseases in both humans and animals. Th...
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Article
Enzymatic and Microbial Biosynthesis of Novel Violacein Glycosides with Enhanced Water Solubility and Improved Anti-nematode Activity
Violacein, a microbial metabolite with multiple applications, was produced in Escherichia coli, and glycodiversified using purified Bacillus glycosyltransferase (YjiC) enzyme with glucose, galactose, and N-acetyl...
