![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Open AccessDevelopment of selective blockers for Ca2+-activated Cl- channel using Xenopus laevis oocytes with an improved drug screening strategy
Ca2+-activated Cl- channels (CaCCs) participate in many important physiological processes. However, the lack of effective and selective blockers has hindered the study of these channels, mostly due to the lack of...
-
Article
One step beyond lethal equivalents: characterization of deleterious loci in the rapid cycling Brassica rapa L. base population
The total number of lethal equivalents as defined by Morton, Crow and Muller (1956) is a function of three parameters: M, the number of loci at which deleterious mutations can occur, q, the frequency of the de...
-
Chapter and Conference Paper
Assessment of Deleterious Gene Models Using Predictive p-values
Using both hierarchical modeling and Bayesian computing techniques, Lee, Newton, Nordheim and Kang (1994) proposed a complex statistical model for studying the characteristics of deleterious genes in plant spe...
-
Article
Number of lethal equivalents in human populations: how good are the previous estimates?
Lee et al. (1996) recently developed a method for interval estimation of the number of lethal equivalents by using a hierarchical structure of likelihood functions. This hierarchical model consists of two multino...