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Article
Open AccessA Comprehensive Review of Over the Counter Treatment for Chronic Low Back Pain
Chronic low back pain (CLBP) is a major contributor to societal disease burden and years lived with disability. Nonspecific low back pain (LBP) is attributed to physical and psychosocial factors, including lif...
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Article
A Comprehensive Review of the Celiac Plexus Block for the Management of Chronic Abdominal Pain
Chronic abdominal pain (CAP) is a significant health problem that can dramatically affect quality of life and survival. Pancreatic cancer is recognized as one of the most painful malignancies with 70–80% suffe...
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Article
Open AccessDeep Learning for Improved Risk Prediction in Surgical Outcomes
The Norwood surgical procedure restores functional systemic circulation in neonatal patients with single ventricle congenital heart defects, but this complex procedure carries a high mortality rate. In this st...
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Article
The Role of the Cannabinoid System in Pain Control: Basic and Clinical Implications
The purpose of this review is to provide a comprehensive update of the different known components of the endogenous cannabinoid system and the mechanisms of action, as it applies to analgesia.
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Article
Emergence Delirium in Perioperative Pediatric Care: A Review of Current Evidence and New Directions
Emergence delirium (ED) is defined as psychomotor agitation and delirium that typically occurs within 45 min from emergence of anesthesia. Preoperative patient conditions such as anxiety and confusion are risk...
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Article
A Comprehensive Update on the Treatment and Management of Postdural Puncture Headache
The purpose of this manuscript is to provide a comprehensive review of postdural puncture headache (PDPH) with a focus on epidemiology, pathophysiology, treatment, and prophylaxis.
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Article
A Comprehensive Review of Over-the-counter Treatment for Chronic Migraine Headaches
Migraine headaches are a neurologic disorder characterized by attacks of moderate to severe throbbing headache that are typically unilateral, exacerbated by physical activity, and associated with phonophobia, ...
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Article
Minimally Invasive Treatment of Chronic Ankle Instability: a Comprehensive Review
Chronic ankle pain is a prevalent and significant cause of chronic pain. While the definition of chronic ankle pain is heterogeneous and poorly defined in the literature, systematic reviews and meta-analyses h...
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Article
Off-label Antidepressant Use for Treatment and Management of Chronic Pain: Evolving Understanding and Comprehensive Review
While clinicians have been using antidepressants for off-label indications in the treatment of chronic pain in recent years, newer studies have proven effectiveness and provided additional mechanistic understa...
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Article
Open AccessA Brief History of the Opioid Epidemic and Strategies for Pain Medicine
The opioid epidemic has resulted from myriad causes and will not be solved by any simple solution. Consequent to a staggering increase in opioid-related deaths in the USA, various governmental inputs and stake...
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Article
Novel Interventional Nonopioid Therapies in Headache Management
Headaches encompass a broad-based category of a symptom of pain in the region of the head or neck. For those patients who unfortunately do not obtain relief from conservative treatment, interventional techniqu...
