7 Result(s)
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Article
Open AccessTFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis
Fatty liver is a highly heterogenous condition driven by various pathogenic factors in addition to the severity of steatosis. Protein insufficiency has been causally linked to fatty liver with incompletely def...
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Article
Open AccessIslet autoantibody seroconversion in type-1 diabetes is associated with metagenome-assembled genomes in infant gut microbiomes
The immune system of some genetically susceptible children can be triggered by certain environmental factors to produce islet autoantibodies (IA) against pancreatic β cells, which greatly increases their risk ...
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Article
Open AccessWestern-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model
The prevalence of maternal obesity is increasing in the United States. Offspring born to women with obesity or poor glycemic control have greater odds of becoming obese and develo** metabolic disease later i...
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Open AccessAuthor Correction: The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessThe gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD
Maternal obesity is associated with increased risk for offspring obesity and non-alcoholic fatty liver disease (NAFLD), but the causal drivers of this association are unclear. Early colonization of the infant ...
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Article
Open AccessAltered gene expression and metabolism in fetal umbilical cord mesenchymal stem cells correspond with differences in 5-month-old infant adiposity gain
The intrauterine period is a critical time wherein developmental exposure can influence risk for chronic disease including childhood obesity. Using umbilical cord-derived mesenchymal stem cells (uMSC) from off...
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Open AccessGenomic Variants Associated with Resistance to High Fat Diet Induced Obesity in a Primate Model
Maternal obesity contributes to an increased risk of lifelong morbidity and mortality for both the mother and her offspring. In order to better understand the molecular mechanisms underlying these risks, we pr...
