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Article
Open AccessThe transposable element-derived transcript of LIN28B has a placental origin and is not specific to tumours
Transposable elements (TEs) are genetic elements that have evolved as crucial regulators of human development and cancer, functioning as both genes and regulatory elements. When TEs become dysregulated in canc...
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Article
Aberrant Immunoglobulin Kappa Locus Rearrangement in a Patient with CARD11-Related B Cell Lymphocytosis
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Article
Open AccessSilencing of Testin expression is a frequent event in spontaneous lymphomas from Trp53-mutant mice
The tumour suppressor gene, TES, is frequently methylated in many human tumours. Previously, we demonstrated that TES promoter methylation and transcriptional silencing was the most common molecular abnormality d...
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Article
Open AccessA streamlined method for analysing genome-wide DNA methylation patterns from low amounts of FFPE DNA
Formalin fixed paraffin embedded (FFPE) tumor samples are a major source of DNA from patients in cancer research. However, FFPE is a challenging material to work with due to macromolecular fragmentation and nu...
