16 Result(s)
within
Jack Bowden
Biomedicine, general
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Article
Open AccessPolygenic scores for cardiovascular risk factors improve estimation of clinical outcomes in CCB treatment compared to pharmacogenetic variants alone
Pharmacogenetic variants are associated with clinical outcomes during Calcium Channel Blocker (CCB) treatment, yet whether the effects are modified by genetically predicted clinical risk factors is unknown. We...
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Article
Open AccessEffects of physical activity and sedentary time on depression, anxiety and well-being: a bidirectional Mendelian randomisation study
Mental health conditions represent one of the major groups of non-transmissible diseases. Physical activity (PA) and sedentary time (ST) have been shown to affect mental health outcomes in opposite directions....
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Article
Open AccessBody mass index and inflammation in depression and treatment-resistant depression: a Mendelian randomisation study
Major depressive disorder (MDD) has a significant impact on global burden of disease. Complications in clinical management can occur when response to pharmacological modalities is considered inadequate and sym...
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Open AccessMendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality
Extensive evidence links higher body mass index (BMI) to higher odds of depression in people of European ancestry. However, our understanding of the relationship across different settings and ancestries is lim...
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Open AccessApplying Mendelian randomization to appraise causality in relationships between nutrition and cancer
Dietary factors are assumed to play an important role in cancer risk, apparent in consensus recommendations for cancer prevention that promote nutritional changes. However, the evidence in this field has been ...
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Article
Open AccessRealising the full potential of MR-PHeWAS in cancer
MR-PHeWAS is a powerful new design for discovering causal mechanisms between a disease and its many candidate risk factors in a hypothesis-free manner. This technique has great potential in the field of cancer...
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Article
Biological and clinical insights from genetics of insomnia symptoms
Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood...
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Article
Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits
Richa Saxena and colleagues report genome-wide association analyses of sleep disturbance traits in the UK Biobank cohort. They discover loci associated with insomnia symptoms and excessive daytime sleepiness a...
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Open AccessCorrecting for selection bias in two-stage trials with multiple correlated outcomes: application to seamless phase ii/iii clinical trials
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Article
Open AccessPatient drift and response-adaptive randomisation: impact and solutions
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Article
Open AccessType I error control in biomarker-stratified clinical trials
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Article
Open AccessRevisiting the multi-armed bandit model for the optimal design of clinical trials: benefits and drawbacks
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Article
Open AccessImpact of lack-of-benefit stop** rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome
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Article
Open AccessAdaptive enrichment in biomarker-stratified clinical trial design
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Article
Open AccessImpact of lack-of-benefit stop** rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome
In 2011, Royston et al. described technical details of a two-arm, multi-stage (TAMS) design. The design enables a trial to be stopped part-way through recruitment if the accumulating data suggests a lack of benef...
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Open AccessDesigning a preliminary adaptive study to inform a biomarker trial in Psoriasis
