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  1. No Access

    Article

    Mechanisms involved in the induction of apoptosis by T-2 and HT-2 toxins in HL-60 human promyelocytic leukemia cells

    T-2 and HT-2 toxins belong to a group of mycotoxins that are widely encountered as natural contaminants known to elicit toxic responses in hematopoietic cells. In the present study, HL-60 cells were used to ch...

    J.A. Holme, E. Morrison, J.T. Samuelsen, R. Wiger, M. Låg… in Cell Biology and Toxicology (2003)

  2. No Access

    Article

    Estrogen-like properties of brominated analogs of bisphenol A in the MCF-7 human breast cancer cell line

    Tetrabromobisphenol A (TeBBPA) is a four-meta-brominated variant of bisphenol A (BPA) and is one of the most commonly used brominated flame retardants worldwide. We compared the estrogenic potency of TeBBPA, BPA ...

    M. Samuelsen, C. Olsen, J.A. Holme, E. Meussen-Elholm… in Cell Biology and Toxicology (2001)

  3. No Access

    Article

    Single-strand breaks, cell cycle arrest and apoptosis in HL-60 and LLCPK1 cells exposed to 1,2-dibromo-3-chloropropane

    We investigated 1,2-dibromo-3-chloropropane (DBCP)-induced DNA damage, cell cycle alterations and cell death in two cell lines, the human leukemia HL-60 and the pig kidney LLCPK1, both of which are derived from p...

    R. Wiger, J.A. Holme, J.K. Hongslo, G. Brunborg, K. Haug… in Cell Biology and Toxicology (1998)

  4. No Access

    Chapter and Conference Paper

    Effects of Chemical-Induced DNA Damage on Male Germ Cells

    Several recent studies indicate declines in sperm production, as well as increases in the incidence of genitourinary abnormalities such as testicular cancer, cryptorchidism and hypospadias (Toppari et al., 199...

    J. A. Holme, C. Bjørge, M. Trbojevic… in Diversification in Toxicology — Man and En… (1998)

  5. No Access

    Chapter and Conference Paper

    Selective Cellular Toxicity After Exposure to 4-Ipomeanol, Bromobenzene (BrBz) and 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) in Rat Lungs

    The many different cell types identified in the lungs show a broad variation in morphology, function and metabolic capacity. Because of this variation certain cell types are more susceptible to the toxic insul...

    R. Becher, G. Brunborg, M. Låg, J. A. Holme, E. J. Søderlund… in Medical Toxicology (1992)

  6. No Access

    Chapter

    Testicular Metabolism and Toxicity of Halogenated Propanes

    A number of cases of infertility were discovered in 1977 among men working in a factory formulating the nematocide 1,2-dibromo-3-chloropropane (DBCP) (Whorton et al., 1977). These workers were found to have az...

    E. Dybing, E. J. Soderlund, M. Låg, G. Brunborg… in Biological Reactive Intermediates IV (1991)