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Article
Anaerobic ammonium oxidation by marine and freshwater planctomycete-like bacteria
Recently, two fresh water species, "Candidatus Brocadia anammoxidans" and "Candidatus Kuenenia stuttgartiensis", and one marine species, "Candidatus Scalindua sorokinii", of planctomycete anammox bacteria have be...
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Article
Genome sequence of the plant pathogen Ralstonia solanacearum
Ralstonia solanacearum is a devastating, soil-borne plant pathogen with a global distribution and an unusually wide host range. It is a model system for the dissection of molecular determinants governing pathogen...
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Article
Linkage analysis of candidate myelin genes in familial multiple sclerosis
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system. A complex genetic etiology is thought to underlie susceptibility to this disease. The present study was designed t...
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Article
Identification and map** of 26 human testis mRNAs containing CAG/CTG repeats
Various types of pathologies, including neurodegenerative diseases, as well as different types of neoplasia, are related to genes exhibiting simple tandem repeat instabilities. In order to seek for new candid...
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Article
A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex
Multiple sclerosis (MS), an inflammatory autoimmune demyelinating disorder of the central nervous system, is the most common cause of acquired neurological dysfunction arising in the second to fourth decades o...
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Article
Evidence of genetic heterogeneity of Leber's congenital amaurosis (LCA) and map** of LCA1 to chromosome 17p13
Leber's congenital amaurosis (LCA) is an autosomal recessive disease responsible for congenital blindness. It is the earliest and most severe inherited retinal dystrophy in human and its genetic heterogeneity ...
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Article
Regional assignment of human ESTs by whole-genome radiation hybrid map**
The UK HGMP Resource Centre’s collection of human partial cDNA sequences (ESTs) have been examined for suitability for map** by PCR on a panel of somatic cell hybrids. The chromosomal assignments of 92 ESTs ...
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Article
The gene for X-linked hypophosphataemic rickets maps to a 200–300 kb region in Xp22.1, and is located on a single YAC containing a putative vitamin D response element (VDRE)
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Article
Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13
Loss of heterozygosity (LOH) on chromosome 13 occurs on 25-30% of breast tumours. This may reflect the inactivation of the retinoblastoma susceptibility gene RB1. However, recently another candidate tumour-sup...
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Article
An international two–stage genome–wide search for schizophrenia susceptibility genes
Schizophrenia is thought to be a multifactorial disease with complex mode of inheritance1,2. Using a two-stage strategy for another complex disorder, a number of putative IDDM-susceptibility genes have recently b...
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Article
The gene for autosomal dominant cerebellar ataxia with pigmentary macular dystrophy maps to chromosome 3p12–p21.1
Autosomal dominant cerebellar ataxia with pigmentary macular dystrophy (ADCA type II) is a rare neurodegenerative disorder with marked anticipation. We have mapped the ADCA type II locus to chromosome 3 by lin...
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Article
Genetic map** of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome llq
LOCI in the major histocompatibility complex (MHC) on chromo-some 6 and the insulin (INS) region on chromosome 11 have been implicated in susceptibility to insulin-dependent diabetes mellitus (IDDM) through candi...
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Article
A radiation hybrid map of 506 STS markers spanning human chromosome 11
We present a high resolution radiation hybrid map of human chromosome 11 using 506 sequence tagged sites (STSs) scored on a panel of 86 radiation hybrids. The 506 STSs fall into 299 unique positions (average r...
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Article
Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain
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Map** of the hypokalaemic periodic paralysis (HypoPP) locus to chromosome 1q31–32 in three European families
Hypokalaemic periodic paralysis (HypoPP) is an autosomal dominant muscle disease thought to arise from an abnormal function of ion channels. Performing a genome–wide search using polymorphic dinucleotide repea...
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Article
A first-generation physical map of the human genome
SETS of ordered overlap** cloned genomic DNA fragments that span each of the human chromosomes are urgently needed for identification of human disease genes. Such a physical map also provides unique material to...
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Article
A gene for Hirschsprung disease maps to the proximal long arm of chromosome 10
Hirschsprung disease (HSCR) is a frequent congenital disorder (1 in 5,000 newborns) of unknown origin characterized by the absence of parasympathetic intrinsic ganglion cells of the hindgut. Taking advantage o...
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Article
Map** of a novel gene for familial hypertrophic cardiomyopathy to chromosome 11
Familial hypertrophic cardiomyopathy (FHC) is a cardiac disorder transmitted as an autosomal dominant trait. FHC has been shown to be genetically heterogeneous with less than 50% of published pedigrees being a...
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Article
Correction: Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus
Nature 356, 162-164 (1992) THE following was omitted from the Acknowledgements section of this Letter: "This work was supported in part by a NIH grant to M.A.P. Y.T. was a recipient of a mentor based fellowshi...
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Article
Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus
NON-INSULIN-DEPENDENT diabetes mellitus (NIDDM) is a major health problem, affecting 5% of the world population. Genetic factors are important in NIDDM, but the mechanisms leading to glucose intolerance are un...
