Effectors of Thermogenesis
Proceedings of a Symposium held at Geneva (Switzerland) on 14 to 16 July 1977
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Article
Warthin-Tumor mit Karzinom
Wir berichten über einen ungewöhnlichen Fall eines langjährig klinisch diagnostizierten Warthin-Tumors (WT) mit plötzlicher Größenzunahme und nachfolgender Resektion. Histologisch konnte der WT bestätigt werde...
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Article
β-Adrenergic control of stearoyl-CoA desaturase 1 repression in relation to sympathoadrenal regulation of thermogenesis
Mice lacking β-adrenoceptors, which mediate the thermogenic effects of norepinephrine and epinephrine, show diminished thermogenesis and high susceptibility to obesity, whereas mice lacking stearoyl-CoA desaturas...
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Article
The thrifty ‘catch-up fat’ phenotype: its impact on insulin sensitivity during growth trajectories to obesity and metabolic syndrome
The analyses of large epidemiological databases have suggested that infants and children who show catch-up growth, or adiposity rebound at a younger age, are predisposed to the development of obesity, type 2 d...
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Article
Substrate cycling between de novo lipogenesis and lipid oxidation: a thermogenic mechanism against skeletal muscle lipotoxicity and glucolipotoxicity
Life is a combustion, but how the major fuel substrates that sustain human life compete and interact with each other for combustion has been at the epicenter of research into the pathogenesis of insulin resist...
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Article
Skeletal muscle heterogeneity in fasting-induced upregulation of genes encoding UCP2, UCP3, PPARγ and key enzymes of lipid oxidation
The uncoupling protein homologs UCP2 and UCP3 have been proposed as candidate genes for the regulation of lipid metabolism. Within the context of this hypothesis, we have compared, from fed and fasted rats, c...
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Article
Downregulation of skeletal muscle UCP-3 gene expression during refeeding is prevented by cold exposure
We wished to gain insights into the role of skeletal muscle uncoupling protein-3 (UCP-3) in the elevated efficiency of fat recovery during refeeding after starvation. Previous observations have revealed that m...
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Article
Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity
The thermogenic effect of tea is generally attributed to its caffeine content. We report here that a green tea extract stimulates brown adipose tissue thermogenesis to an extent which is much greater than can ...
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Article
Skeletal muscle UCP3 and UCP2 gene expression in response to inhibition of free fatty acid flux through mitochondrial β-oxidation
Studies of starvation and refeeding have implicated the genes coding for uncoupling protein-3 and -2 (UCP3, UCP2) as candidate genes in the regulation of lipids as metabolic fuels in skeletal muscle. To gain ins...
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Article
Real-time measurement of the contribution of the muscular activity to the metabolic rate in freely moving rats
A new real-time ergometric system, ERGORAT, for measuring the energy expenditure due to muscular activity of small mammals is described. The method is based on measuring the vibrations induced by a freely movi...
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Chapter and Conference Paper
Investigation of the Reaction \( \bar pp \to \bar \Lambda \Lambda \) Close to Threshold at LEAR
Measurements of observables in antihyperon—hyperon production following the antiproton—proton collision in the threshold region offer an excellent opportunity to examine the dynamics of strangeness creation. A...
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Chapter and Conference Paper
Feasibility of CP-Invariance Test in \( \bar YY \) Y Production
In another contribution at this conference the PS185 threshold decay spectrometer was presented. Beside other observables the polarization has been analyzed independently in the
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Article
Study of the reaction \(\bar pp \to \bar \Lambda \Lambda \) close to threshold at LEARp→⊼Λ close to threshold at LEAR
The reaction \(\bar pp \to \bar \Lambda \Lambda \) is related to the creation of a strange-antistrange quark pair....
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Article
Prepontine knife cut-induced hyperthermia in the rat
The effect of brown adipose tissue (BAT) denervation on the prepontine knife cut-induced hyperthermia was studied. The knife cut has earlier been shown to induced a steady state hyperthermia of 3 to 4°C, as a ...
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Article
Evidence for a modulating effect of NA+/H+ exchange on the metabolic response of rat brown adipose tissue
Membrane potential and intracellular pH (pHi) were simultaneously monitored in rat perifused brown adipose tissue fragments by means of double-barrelled microelectrodes. In parallel experiments, the respirator...
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Chapter and Conference Paper
Hyperon-antihyperon production studies near threshold at LEAR
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Article
Is there a sympathetic regulation of the efficiency of energy utilization?
Brown adipose tissue, a well known effector of regulatory thermogenesis found in mammals, is unique in its ability to steadily increase its heat production several fold for very long periods of time. It consti...
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Article
Absorption kinetics of subcutaneously injected insulin
The absorption of subcutaneously injected insulin was examined by injecting semisynthetic [3H] insulin in anaesthetized pigs and subsequently analysing the tissue excised from the injection site. Contrary to prev...
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Book and Conference Proceedings
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Chapter and Conference Paper
Does Cytoplasmic Alkalinization Trigger Mitochondrial Energy Dissipation in the Brown Adipocyte?
Indirect calorimetry measurements showed that brown fat thermogenesis was very sensitive to modifications of intracellular pH induced by extracellular acid-base perturbations. Specific blockage of active Na-K ...
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Article
Control of brown fat thermogenesis by the sympathetic nervous system
